中国比较医学杂志2018，Vol.28Issue(1)：118-122,5.DOI:10.3969/j.issn.1671-7856.2018.01.021
人源性肿瘤组织原位异种移植模型的特征及研究策略
Characteristics and research strategies of patient-derived orthotopic xenograft models
摘要
Abstract
The patient-derived orthotopic xenograft (PDOX) model better maintains the genetic characteristics of the primary tumor, and keep stable in histology, transcriptome, polymorphism and copy number variations. It also retains the interaction between the tumor mesenchyma, microvessels and stroma, and the tumor metastatic properties. Therefore, PDOX model can predict disease prognosis more accurately and can be used to screen appropriate individualized treatment strategies, thus, shows perfect prospect in clinical application. However, due to the differences between mouse and human microenvironment, morphological distinctions between orthotopic xenograft tumors and primary tumors still exist, and tumor metastasis can not be ensured by orthotopic xenograft. Thus, in order to construct the individualized PDOX model and to promote its clinical translation, it is necessary to analyze the histomorphology of orthotopic xenografts, to establish database of the transplantation model and share the information of the model. In this review, we will summarize the main features of PDOX models with its advantages and limitations, and looking forward to its application in the future.关键词
人源性肿瘤组织原位异种移植/肿瘤微环境/转移Key words
patient-derived orthotopic xenograft/PDOX/tumor microenvironment/metastasis分类
医药卫生引用本文复制引用
陈薛,张贺,师长宏..人源性肿瘤组织原位异种移植模型的特征及研究策略[J].中国比较医学杂志,2018,28(1):118-122,5.基金项目
国家自然科学基金(编号: 31572340) （编号: 31572340）
军队实验动物专项课题(编号: SYDW2016-006). （编号: SYDW2016-006）
