中国比较医学杂志2018，Vol.28Issue(1)：123-128,6.DOI:10.3969/j.issn.1671-7856.2018.01.022
P301L突变tau蛋白转基因动物模型及其应用
P301L tau transgenic animal models and their applications
摘要
Abstract
Tau protein, a kind of microtubule-associated protein, plays an important role in the pathogenesis of Alzheimer's disease (AD) and other tauopathies, and has drawn more and more attention of scientific researchers. Appropriate animal models of mutated tau protein are important in the studies of the pathogenesis and drug therapy of tauopathies. So far, some transgenic animal models expressing human tau protein have been established, among which the transgenic animal model overexpressing P301L mutated form of tau protein has been widely used because of its obvious pathological changes. In this review, we will review the research progress in the pathological manifestations of the P301L tau transgenic animal model and its applications in pharmacological studies.关键词
P301L突变/tau蛋白/转基因小鼠/阿尔茨海默病/tau蛋白病Key words
P301L mutation/tau protein/transgenic mice/Alzheimer's disease/tauopathies分类
医药卫生引用本文复制引用
马登磊,张如意,李林..P301L突变tau蛋白转基因动物模型及其应用[J].中国比较医学杂志,2018,28(1):123-128,6.基金项目
国家自然科学基金项目(编号: 81673406) （编号: 81673406）
北京市科技专项 (编号: Z131102002813066) （编号: Z131102002813066）
北京市高层次卫生技术人才计划 (编号: 2011-1-7) （编号: 2011-1-7）
首都卫生发展科研专项(编号:首 发2016-2-1033). （编号:首 发2016-2-1033）
