中国比较医学杂志2018，Vol.28Issue(6)：1-3,3.DOI:10.3969/j.issn.1671-7856.2018.06.001
心房钠尿肽在基因敲除小鼠黑色素瘤肺转移中的作用
Effect of atrial natriuretic peptide ( ANP) on pulmonary melanoma metastasis in ANP knockout mice and C57BL／6J mice
摘要
Abstract
Objective To investigate the role of atrial natriuretic peptide (ANP) in lung metastasis of melanoma. Methods Melanoma B16F10 cells were intravenously injected into ANP knockout mice and C57BL／6J mice. After three weeks, the mice were sacrificed, and the lungs were removed, embedded, and examined by pathology using HE staining. The numbers of metastatic foci on the lung surface and micrometastatic foci in the lung tissues were counted. Results The ANP knockout mice displayed fewer metastatic foci on the lung surface and less micrometastatic foci in the lung tissues of ANP knockout mice than in the C57BL／6J mice. Conclusions ANP deletion significantly suppresses the metastasis of melanoma in the lung of mice.关键词
心房钠尿肽/基因敲除小鼠/黑色素瘤/肺转移瘤Key words
atrial natriuretic peptide, ANP/ gene knockout mice/ melanoma/ lung metastasis分类
医药卫生引用本文复制引用
亓翠玲,曹静桦,何亚军,李倩明,李梦诗,杨扬,王丽京..心房钠尿肽在基因敲除小鼠黑色素瘤肺转移中的作用[J].中国比较医学杂志,2018,28(6):1-3,3.基金项目
国家自然科学基金(31500966,81773095) （31500966,81773095）
广州市科技计划项目(201607010135) （201607010135）
广东省科技计划项目(2015A020211029, 2014A020212314). （2015A020211029, 2014A020212314）
