中国现代医学杂志2018，Vol.28Issue(18)：14-18,5.DOI:10.3969/j.issn.1005-8982.2018.18.003
梗阻性肾病肾组织中磷酸化黏着斑激酶的表达及意义
Expression and significance of phosphorylated FAK in renal tissue of obstructive nephropathy
摘要
Abstract
Objective To investigate the expression and significance of FAK on renal fibrosis of obstructive nephropathy. Methods Unilateral ureteral ligation was performed to establish rat model of obstructive nephropathy (UUO model). The rats were divided into 3 groups: sham group, injury group (3 days) and injury group (14 days). The expression of FAK, α-SMA and integrin β1(CD29) in renal tissue of rats were detected by immunohistochemistry and western blot. Results Immunohistochemical staining and western blot showed that expression of FAK, α-SMA and integrin β1in injury group (3 d) was significantly increased compared with that in sham group (P ＜ 0.05) while expression of FAK in injury group (14 d) was higher than that in injury group (3 d) (P ＜ 0.05). Conclusion Increased expression of p-FAK in renal tissue promotes fibrosis through integrin β1mediated formation of myofibroblast.关键词
肾纤维化/纤维化/整合素β1/黏着斑激酶Key words
renal fibrosis/fibrosis/integrin beta 1/FAK分类
医药卫生引用本文复制引用
陈志,李冰晟,何垚,王朝晖,张波,杜勇超,刘雨杭,陈湘..梗阻性肾病肾组织中磷酸化黏着斑激酶的表达及意义[J].中国现代医学杂志,2018,28(18):14-18,5.基金项目
湖南省自然科学基金(No:2015JJ2152) （No:2015JJ2152）
湖南省自然科学青年基金(No:2015JJ3162) （No:2015JJ3162）
