中国现代医学杂志2018，Vol.28Issue(18)：50-55,6.DOI:10.3969/j.issn.1005-8982.2018.18.010
血清抗凝血酶Ⅲ、纤维蛋白原对高危NSTE-ACS患者的评估价值
Predictive significance of antithrombin Ⅲ and fibrinogen in patients with non-ST segment-elevation acute coronary syndrome
徐通达 1陈超 1李东野 1张延斌 1陈军红 1宣皓晨 1王超凡1
作者信息
- 1. 徐州医科大学附属医院 心内科,江苏 徐州 221002
- 折叠
摘要
Abstract
Objective To explore the predictive value of plasma antithrombinⅢ and fibrinogen in patients with non-ST segment-elevation acute coronary syndrome (NSTE-ACS). Methods Totally 280 patients diagnosed with NSTE-ACS admitted into the hospital from January 2015 to December 2016 were involved. Forty healthy subjects were regarded as control group. Patients in NSTE-ACS group were further divided into low risk group (score ≤108, 47 cases), moderate risk group (109 ≤ score ≤ 140, 106 cases) and high risk group (score ＞ 106, 127 cases) according to GRACE score. Levels of plasma AT-Ⅲ and FIB were measured. Correlation analysis were performed between AT-Ⅲ, FIB level and GRACE score. Multi-factor linear regression was conducted to identify independent predictive factors of GRACE score. ROC curve analysis was utilized to evaluate the significance of AT- Ⅲ and FIB in NSTE-ACS patients. Logistic multivariate regression analysis was performed to find independent predictive factors of NSTE-ACS. Results Compared with the control group, levels of AT-Ⅲ decreased while FIB increased significantly in experimental group (P ＜ 0.05). GRACE score was negatively correlated with AT-Ⅲ (r = -0.494, P ＜ 0.05) while positively correlated with FIB level (r = 0.513, P ＜ 0.05). AT- Ⅲ and FIB are independent predictive factors of GRACE score (P ＜ 0.05). The ROC curve analysis showed that the AUC for AT-Ⅲ and FIB were 0.797 and 0.756, respectively (P ＜ 0.05). Cut-off point was 85.50 and 4.03 for AT-Ⅲand FIB, respectively. Sensitivity for AT- Ⅲ and FIB were 69%, 66% and the specificity were 91%, 93%, respectively. Conclusions Plasma AT- Ⅲ and FIB are both independent predictive factors in evaluating risk stratification for high risk of NSTE-ACS.关键词
非ST段抬高型急性冠状动脉综合征/GRACE评分/血清抗凝血酶Ⅲ/纤维蛋白原/冠状动脉造影Key words
non st segment elevation acute coronary syndrome/grace score/antithrombin Ⅲ/fibrinogen/coronary angiography分类
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徐通达,陈超,李东野,张延斌,陈军红,宣皓晨,王超凡..血清抗凝血酶Ⅲ、纤维蛋白原对高危NSTE-ACS患者的评估价值[J].中国现代医学杂志,2018,28(18):50-55,6.
