中国现代医学杂志2018，Vol.28Issue(18)：62-66,5.DOI:10.3969/j.issn.1005-8982.2018.18.012
Ⅲ型胶原蛋白α1链基因rs1800255多态性与颅内动脉瘤发病关系的系统评价
Association of Type Ⅲ collagen alpha 1 rs1800255 polymorphism with intracranial aneurysm
付晓红 1赵敏 2余云湖 1周航 1付臣志3
作者信息
- 1. 贵州省遵义市第一人民医院 神经外科,贵州 遵义563000
- 2. 贵州省遵义市第一人民医院 药剂科,贵州 遵义563000
- 3. 贵州省桐梓县人民医院 神经外科,贵州 桐梓 563200
- 折叠
摘要
Abstract
Objective To investigate the association between Type Ⅲ collagen alpha 1 rs1800255 polymorphism and intracranial aneurysm (IA) incidence. Methods Case-control studies between rs1800255 G ＞ A polymorphism and IA risk were searched in NCBI PubMed, CNKI and Wanfang database. Stata 12.0 software was utilzied to detect the publication bias and heterogeneity across the data. Inclusion and exclusion criteria were formulated. Results Until July 31st, 6 studies with 3,664 subjects were included. Meta-analysis showed that, in the dominant genetic model, rs1800255 G ＞ A polymorphism was significantly associated with IA. Compared with the GG genotype, A allele carrier experienced significantly increased risk of IA with pooled (O^R) equal to 1.68 and corresponding 95% CI as 1.43 to 1.98. Compared with the GG+GA genotype, in the recessive genetic model, AA genotype subjects had significantly increased risk of IA with pooled (O^R) equal to 1.62 and corresponding 95% CI as 1.12 to 2.35. Conclusion COL3A1 gene rs1800255 G ＞ A polymorphism may modify the susceptibility of person to IA.关键词
Ⅲ型胶原蛋白α1链基因/多态性/颅内动脉瘤/发病风险Key words
type Ⅲ collagen alpha l/ polymorphism/ intracranial aneurysm/ risk of disease分类
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付晓红,赵敏,余云湖,周航,付臣志..Ⅲ型胶原蛋白α1链基因rs1800255多态性与颅内动脉瘤发病关系的系统评价[J].中国现代医学杂志,2018,28(18):62-66,5.
