中国现代医学杂志2018，Vol.28Issue(20)：57-60,4.DOI:10.3969/j.issn.1005-8982.2018.20.0010
IDMs合并心肌损害对GPBB的影响及其意义
Serum GPBB level and its clinical significance in infants of diabetic mothers
摘要
Abstract
Objective?To detect the serum level of glycogen phosphorylase isozyme BB (GPBB) in infants of diabetic mothers (IDMs) with myocardial damage and discuss its clinical significance.?Methods?Totally 132 IDMs who were admitted to the Neonatal Ward in the Affiliated Hospital of Hebei University from January to December 2014 were selected as the study subjects. Their blood GPBB level was detected at 3, 6, 12 and 24 h after birth, and compared with the control group. Of the 132 IDMs, 40 were diagnosed as myocardial damage (myocardial damage group) and 92 did not have myocardial damage (non-myocardial damage group). And the GPBB levels were compared among myocardial damage group, non-myocardial damage group and control group at each time point. The correlations between GPBB level and the perinatal risk factors were also discussed.?Rusults?The GPBB level of the myocardial damage group was higher than those of the non-myocardial damage group and the control group at 3, 6, 12 and 24 h after birth (P < 0.05). GPBB level was greatly affected by poor control of serum glucose in the mothers during pregnancy, long course of gestational diabetes (≥ 3 months), and neonatal hypoglycemia (P < 0.05).?Conclusions?GPBB could be used as an early sensitive marker of myocardial damage in IDMs.关键词
糖原磷酸化酶同功酶脑型/糖尿病母亲婴儿/心肌损伤Key words
glycogen phosphorylase BB/infants of diabetic mothers/myocardial damage分类
医药卫生引用本文复制引用
魏继红,姬静璐,谭笑,王欣,张欢欢,柏金秀..IDMs合并心肌损害对GPBB的影响及其意义[J].中国现代医学杂志,2018,28(20):57-60,4.基金项目
河北省临床医学优秀人才培养项目(No :361007) （No :361007）
