中国现代医学杂志2018，Vol.28Issue(20)：61-64,4.DOI:10.3969/j.issn.1005-8982.2018.20.011
维生素E对膝骨性关节炎的疗效分析
Effect of vitamin E on knee osteoarthritis
摘要
Abstract
Objective?To investigate the effect of vitamin E on the level of oxidative stress and the clinical efficacy in patients with osteoarthritis of the knees.?Methods?The patients with osteoarthritis of the knees in our hospital were prospectively collected from January to December 2016, and divided into an observation group and a control group with 40 cases in each group. The patients of both groups received routine treatment. And the patients in the observation group received additional oral administration of vitamin E. The whole course was 6 months. The oxidative stress reaction and clinical efficacy were compared between the two groups.?Results?There was no significant difference in the level of glutathione peroxidase or superoxide dismutase between the two groups before treatment (P > 0.05). After 6-month treatment, the levels of glutathione peroxidase [(122.73 ± 25.65) vs. (145.92 ± 26.74) μmol/L, P < 0.05] and superoxide dismutase [(104.82 ± 18.94) vs. (122.68 ± 19.84) u/ml, P < 0.05] decreased in the observation group compared with the control group. There was no significant difference in pain score, joint stiffness score, daily activity score or total score of Western Ontario MacMaster University Osteoarthritis index (WOMAC) between the two groups before treatment (P > 0.05). After 6-month treatment, when compared with the control group, the patients in the observation group got decreased pain score, joint stiffness score, daily activity score and total score of WOMAC (P < 0.05). There was no statistical difference in Lysholm knee motor function score between the two groups before treatment (P > 0.05). After treatment for 6 months, the score of Lysholm knee motor function in the observation group was higher than that in the control group [(75.21 ± 10.85) vs. (66.48 ± 10.44), P < 0.05].?Conclusions?Vitamin E can reduce the level of oxidative stress in the patients with osteoarthritis of the knees and improve the joint function of the patients.关键词
维生素E/骨性关节炎/氧化应激/临床疗效Key words
vitamin E/osteoarthritis/oxidative stress/clinical efficacy分类
医药卫生引用本文复制引用
华仲森,陈之青,俞雷钧..维生素E对膝骨性关节炎的疗效分析[J].中国现代医学杂志,2018,28(20):61-64,4.基金项目
浙江省科技厅合作研发和成果转化项目(No :2014F50005) （No :2014F50005）
