中国现代医学杂志2018，Vol.28Issue(20)：65-69,5.DOI:10.3969/j.issn.1005-8982.2018.20.012
麻醉方式对直肠癌患者CD4+CD25+Foxp3+Treg水平及预后的影响
Influence of different anesthesia on level of CD4+CD25+Foxp3+Treg cells and prognosis of patients with rectal cancer
摘要
Abstract
Objective?To investigate the influence of three different anesthesia on level of CD4+CD25+Foxp3+ Treg cells and prognosis of patients with rectal cancer undergoing CO2 pneumoperitoneum laparoscopic surgery.?Methods?A prospective cohort study was carried out in 143 adult patients, who received colorectal cancer surgery under CO2 pneumoperitoneum laparoscope in our hospital between January 2011 and December 2012. The hemodynamic changes in the patients with general anesthesia (GA), combined epidural and general anesthesia (EA), and EA combined with 6% hydroxyethyl starch solution acute hemodilution (EA+AHH) during surgery, the level of CD4+CD25+Foxp3+ Treg cells before operation and 1 month after operation and the survival rate of 3-year follow-up were compared between the three groups.?Results?Compared with the other two groups, the intraoperative blood pressure fluctuation was smaller, the decreased range of CD4+CD25+Foxp3+/CD4+T cell ratio in peripheral blood 1 month after surgery was greater, and the 3-year survival rate was significantly higher in the (EA+AHH) group (P < 0.05). There was no statistically significant difference between the GA and EA groups (P > 0.05).?Conclusions?Acute hypervolemic hemodilution using 6% hydroxyethyl starch combined with epidural anesthesia can significantly improve the immune status and prognosis of the patients with rectal cancer undergoing CO2 pneumoperitoneum laparoscopic surgery.关键词
硬膜外复合全身麻醉联合急性高容量血液稀释/CD4+CD25+Foxp3+Treg细胞/直肠癌/CO2气腹/预后Key words
combined epidural and general anesthesia with acute hypervolemic hemodilution/rectal cancer/CD4+CD25+Foxp3+Treg cell/CO2pneumoperitoneum/prognosis分类
医药卫生引用本文复制引用
王晖,杨春艳,宋宇龙,王臻,白宁..麻醉方式对直肠癌患者CD4+CD25+Foxp3+Treg水平及预后的影响[J].中国现代医学杂志,2018,28(20):65-69,5.基金项目
陕西省科技厅社发攻关项目(No :2012K13-02-23) （No :2012K13-02-23）
