中国药科大学学报2018，Vol.49Issue(3)：272-278,7.DOI:10.11665/j.issn.1000-5048.20180303
蛋白质Neddylation修饰与肿瘤关系的研究进展
Advances of relationship between protein Neddylation and cancer
李清梅 1王淑珍1
作者信息
- 1. 中国药科大学生命科学与技术学院,南京210009
- 折叠
摘要
Abstract
Abnormal modification in protein Neddylation is closely related to the occurrence and progression of various tumors. Studies have shown that the level of enzymes participating in Neddylation is higher than that in normal neighboring tissues,so the relationship between Neddylation and cancer has aroused much concern.Ned-dylation has been considered to be a novel anticancer target. Neddylation inactivation by a first-in-class small molecular inhibitor,MLN4924,induces cell cycle arrest,apoptosis,senescence and autophagy in different tumor cells.MLN4924 also exerts significant anticancer effects by inhibiting tumor angiogenesis and regulating the func-tion of immune cells. In this review,the latest progress of protein Neddylation and tumor cell cycle,apoptosis, senescence,autophagy,angiogenesis and regulation of immunocyte were briefly introduced to provide theoretical reference for the development of antitumor drugs targeting Neddylation.关键词
Neddylation修饰/细胞周期/凋亡/衰老/自噬/血管生成/免疫调节/抗肿瘤Key words
Neddylation/cell cycle/apoptosis/senescence/autophagy/angiogenesis/regulation of immunocyte/antitumor分类
生物科学引用本文复制引用
李清梅,王淑珍..蛋白质Neddylation修饰与肿瘤关系的研究进展[J].中国药科大学学报,2018,49(3):272-278,7.
