中国药房2018，Vol.29Issue(3)：382-385,4.DOI:10.6039/j.issn.1001-0408.2018.03.22
醋酸戈舍瑞林缓释植入剂联合比卡鲁胺片对高龄前列腺癌患者的疗效、认知功能、近期生存率的研究
Therapeutic Efficacy of Goserelin Acetate Sustained-release Implants Combined with Bicalutamide in the Treatment of Elderly Prostate Cancer Patients and Cognitive Function and Short-term Survival Rate Study
摘要
Abstract
OBJECTIVE: To investigate therapeutic efficacy of Goserelin acetate sustained-release implants combined with bicalutamide in the treatment of elderly (≥70 years old) prostate cancer patients, and its effects on cognitive function and short-term survival rate. METHODS: A total of 56 prostate cancer patients treated in our hospital from Nov. 2014 to Nov. 2016 were divided into observation group and control group according to random number table, with 28 cases in each group. Observation group was given maximal androgen blokage (MAB) treatment which was Goserelin acetate sustained-release implant (subcutaneous injection of abdominal wall, 3. 6 mg/ times, once) combined with Bicalutamide tablet (orally, 50 mg/times, qd). Control group received surgical castration, and then was given docetaxel (intravenous dripping on 1st day) combined with Prednisone acetate tablets (lst-21st day, orally, 5 mg/time, bid) after surgery for adjuvant therapy. Treatment course of 2 groups lasted for 3 weeks, and all patients were followed up for 12 months. Clinical efficacy, Montreal cognitive function assessment table (MoCA) score, serum prostate specific antigen (PSA) levels and 12-month survival rate were observed in 2 groups. RESULTS: The total response rate of observation group was significantly higher than that of control group, with statistical significance (P<0. 05). Before treatment, there was no statistical significance in MoCA score and serum PSA levels between 2 groups (P>0. 05). After treatment, MoCA scores of 2 groups were decreased significantly, and the observation group was higher than the control group, with statistical significance (P<0. 05). 6 and 12 months after treatment, serum PSA levels of 2 groups were decreased significantly, and the observation group was significantly lower than the control group, with statistical significance (P<0. 05); 12-month survival rate of observation group (92. 86％) was significantly higher than that of control group (64. 29％), with statistical significance (P< 0. 05). CONCLUSIONS: Nonsteroidal anti-androgen drugs show significant therapeutic efficacy for elderly prostate cancer, reduce cognitive function damage, improve serum PSA levels, therapeutic efficacy and short-term survival rate.关键词
非类固醇抗雄激素药物/最大限度雄激素阻断治疗/醋酸戈舍瑞林缓释植入剂/比卡鲁胺片/高龄/前列腺癌/认知功能/近期生存率Key words
Nonsteroidal anti-androgen drugs/Maximal androgen blokage treatment/Goserelin acetate sustained-release implant/Bicalutamide tablet/Elderly/Prostate cancer/Cognitive function/Short-term survival rate分类
医药卫生引用本文复制引用
蔡波,马利民,郭新..醋酸戈舍瑞林缓释植入剂联合比卡鲁胺片对高龄前列腺癌患者的疗效、认知功能、近期生存率的研究[J].中国药房,2018,29(3):382-385,4.基金项目
国家自然科学基金资助项目(No. 81141056) （No. 81141056）
