中国药房2018，Vol.29Issue(3)：386-389,4.DOI:10.6039/j.issn.1001-0408.2018.03.23
左旋氨氯地平对高龄老年高血压伴阻塞性睡眠呼吸暂停低通气综合征患者的血压干预效果研究
Study on the Intervention Effects of Levamlodipine on Elderly Patients with Hypertension Complicated with Obstructive Sleep Apnea-hypopnea Syndrome
摘要
Abstract
OBJECTIVE: To explore the correlation between obstructive sleep apnea-hypopnea syndrome (OSAHA) and elderly (≥80 year-old) hypertension (HP), and the effects of levamlodipine on antihypertensive effect of elderly patients with HP complicated with OSAHA. METHODS: A total of 90 elderly HP patients were analyzed retrospectively and divided into HP group (30 cases) and HP+OSAHA group (60 cases) according to whether accompanied by OSAHA or not. The latter was divided into HP complicated with mild OSAHA group (20 cases, HP+OSAHA1 group), hypertension complicated with medium OSAHA group (21 cases, HP + OSAHA2 group), HP complicated with severe OSAHA group (19 cases, HP + OSAHA3 group) according the severity of OSAHA. All patients were given Levamlodipine besylate tablet 2. 5 mg taken at a draught, qd, in the morning, for 4 weeks, while continuous positive pressure veritilation was given to treat the obstructive apnea in OSAHA patients. Neck circumference, BMI, apnea hypoventilation index (AHI), Sa02, SBP and DBP (daytime, evening and 24 h) were observed in each group 4 weeks later. The correlation of AHI and Sa02 with SBP and DBP was analyzed by Spearman rank correlation. RESULTS: Neck circumference, BMI, AHI, daytime SBP, evening and 24 h SBP and DBP of HP + OSAHA group were significantly higher than those of HP, while SaO2 of HP + OSAHA group was significantly lower than that of HP group. Neck circumference and BMI of HP+OSAHA2 group and HP+OSAHA3 group were significantly higher than those of HP group; the HP+ OSAHA3 group were higher than the HP+OSAHA2 group. SaO2 of HP+OSAHA2 group and HP+OSAHA3 group were significantly lower than that of HP group; the HP+OSAHA3 group was lower than the HP+OSAHA2 group. AHI, evening and 24 h SBP and DBP of HP+OSAHA group were significantly higher than 6those of HP group; the descending order was as follows: HP+OSAHA3 group>HP+OSAHA2 group>HP+OSAHA1 group. Daytime SBP of HP+OSAHA3 group was significantly higher than that of HP group, with statistical significance (P<0. 001); there was no statistical significance in daytime DBP among those groups (P>0. 05). Results of Spearman rank correlation analysis showed that evening and 24 h SBP and DBP were positively correlated with AHI (P<0. 001) and negatively correlated with SaO2 (P<0. 001). CONCLUSIONS: OSAHA can induce the significant increase of blood pressure in elderly HP patients. Levamlodipine has different influences antihypertensive effect of elderly patients with HP complicated with OSAHA. The drug should be adjusted according to the patient's condition.关键词
左旋氨氯地平/睡眠呼吸暂停综合征/高龄/高血压Key words
Levamlodipine/Obstructive sleep apnea-hypopnea syndrome/Elderly/Hypertension分类
医药卫生引用本文复制引用
王维维,高春燕..左旋氨氯地平对高龄老年高血压伴阻塞性睡眠呼吸暂停低通气综合征患者的血压干预效果研究[J].中国药房,2018,29(3):386-389,4.基金项目
河北省2013年医学科学研究课题计划(No. 20130343) （No. 20130343）
