中国药房2018，Vol.29Issue(3)：405-409,5.DOI:10.6039/j.issn.1001-0408.2018.03.28
复方木尼孜其颗粒辅助治疗黄褐斑疗效与安全性的系统评价
Therapeutic Efficacy and Safety of Compound Muni Ziqi Granules in the Adjuvant Treatment of Chloasma: A Systematic Review
摘要
Abstract
OBJECTIVE: To systematically evaluate therapeutic efficacy and safety of Compound muni ziqi granules in the adjuvant treatment of chloasma, and to provide evidence-based reference for clinical treatment. METHODS; Retrieved from Chinese Journal Full-text Database (CJFD), China Scientific Journal Database (CSJD), Wanfang database, Medline and Embase, randomized controlled trials (RCTs) about therapeutic efficacy (total response rate, cure rate, the decrease level of E2, FSH and LH in serum) and safety of Compound muni ziqi granules alone or combined with routine drug (trial group) vs. routine drug (control group) in the treatment of chloasma were collected. Meta-analysis was conducted by using Rev Man 5. 3 statistical software after data extraction of clinical studies meeting inclusion criteria and quality evaluation with Cochrane systematic evaluator manual 5. 1. 0. RESULTS: Totally 12 RCTs were enrolled, involving 1 100 patients. Results of Meta-analysis showed that total response rate [OR=2. 84, 95％CI(2. 20, 3. 67), P<0. 001], cure rate [OR=2. 11, 95％CI(1. 59, 2. 79),P<0. 001],decrease level of Ez [OR=-98. 64, 95％ CI (-110. 84, -86. 44), P <0. 001], decrease level of FSH [OR=-1. 85, 95％CI(-2. 58,-1. 11),P<0. 001] and decrease level of LH [OR= - 5. 85, 95％ CI (-6. 83, -4. 87), P<0. 001] in trial group were significantly better than control group, with statistical significance. In trial group, a few patients suffered from the increase of menstruation, the decrease of menstruation, temporary pigmentation and transient burnout; but all symptoms did not affect the treatment. CONCLUSIONS: Compound muni ziqi granules show definite clinical efficacy and good response rate in the adjuvant treatment of chloasma with mild ADR.关键词
复方木尼孜其颗粒/黄褐斑/疗效/安全性/系统评价/Meta分析Key words
Compound muni ziqi granules/Chloasma/Therapeutic efficacy/Safety/Systematic review/Meta-analysis分类
医药卫生引用本文复制引用
余通,冯芸,吴欢欢,何水英,张东宁,杨菁,尹海龙,尹强..复方木尼孜其颗粒辅助治疗黄褐斑疗效与安全性的系统评价[J].中国药房,2018,29(3):405-409,5.基金项目
新疆维吾尔自治区重大科技专项项目(No. 2016A03005-2) （No. 2016A03005-2）
