中国药房2018，Vol.29Issue(4)：508-511,4.DOI:10.6039/j.issn.1001-0408.2018.04.19
抗肿瘤药致不良反应15 183例分析
Analysis of 15 183 Cases of ADR Caused by Antineoplastic Drugs
摘要
Abstract
OBJECTIVE: To investigate the characteristics and regularity of ADR induced by antineoplastic drugs and provide reference for safe drug use in clinic. METHODS: ADR reports induced by antineoplastic drugs reported by 108 hospitals during Jan. 2009-Dec. 2016 were collected from PLA ADR Monitoring Center. ADR reports were analyzed respectively in respects of types of ADR reports, patients ' gender and age, administration route, occurrence time, types of antineoplastic drug, the situation of patients suffering tumor, systems/organs involved in ADR, clinical manifestations, outcome, etc. RESULTS: Among 15 183 ADR reports, there were 462 cases of new ADR and 2 873 cases of severe ADR; there were 8 039 male (52. 95％) and 7 144 female (47. 05％). The proportion of severe ADR in female (20. 00％) was significantly higher than male (17. 96％), with statistical significance (P=0. 001). ADR was mainly induced by intravenous administration (90. 53％), and mainly occurred 2-＜7 d after medication (23. 00％). Top 3 drug categories in the list of ADR were platinum antineoplastic drugs (25. 63％), plant-derived antineoplastic drugs and its derivative (24. 42％) and anti-metabolism drugs (18. 50％). Male patients mainly suffered from lung cancer, colorectal cancer and gastric cancer; female patients mainly suffered from breast cancer, lung cancer and colorectal cancer. Systems/organs involved in ADR were gastrointestinal system, hematological system and systemic damage. Main clinical manifestations were nausea, vomiting, myelosuppression, skin rash and fever. Totally 92. 57％ of ADR cases were cured and recovered after treatment, and 5 cases died. CONCLUSIONS: Antineoplastic drugs have high incidence of ADR with serious damage. Clinic should strengthen the monitoring of key population and key drugs so as to reduce the occurrence of ADR.关键词
抗肿瘤药/不良反应/回顾性分析Key words
Antineoplastic drug/ADR/Retrospective analysis分类
医药卫生引用本文复制引用
寇炜,郭代红,田小燕,贾王平,赵靓,王啸宇,胡鹏洲..抗肿瘤药致不良反应15 183例分析[J].中国药房,2018,29(4):508-511,4.基金项目
国家药物政策与基本药物政策研究课题 （）
总后勤部卫生部重点项目(No. BWS14R039) （No. BWS14R039）
