中国药房2018，Vol.29Issue(4)：547-552,6.DOI:10.6039/j.issn.1001-0408.2018.04.28
利妥昔单抗注射液相关性肺炎的Meta分析
Meta-analysis of Rituximab Injection Associated Pneumonia
摘要
Abstract
OBJECTIVE: To systematically evaluate the relationship between rituximab and the occurence of pneumonia, and to provide evidenle-based reference in clinic. METHODS: Retrieved from PubMed, Embase, Cochrane Library, Web of Science, CBM, CNKI, Wanfang database and other database, RCTs, quasi-RCTs, controlled clinical trials were searched from inception to Mar. 2017. After literature screening, data extraction, literature quality evaluation and analysis of bias risk referring to Cochrane Intervention Measure System Evaluation Manual (5. 3 edition), Meta-analysis was conducted by using RevMan 5. 3 software. RESULTS: A total of 16 literatures were finally included, consisting of 14 RCTs and 1 386 patients. The results of Meta-analysis showed that the incidence of rituximab associated pneumonia in observation group was lower than control group, but without statistical significance [OR=1. 19, 95％ CI (0. 75, 1. 91), Z=0. 74, P=0. 46]. Subgroup analysis was conducted according to sample size, multiple-center, intervention dose, there was no statistical significance in the incidence of rituximab-associated pneumonia between 2 groups (P＞0. 05). CONCLUSIONS: There was no significant difference in the incidence of pneumonia between observation group and control group, rituximab is not associated with the occurrence of pneumonia. Due to methodology limit of included studies, most of high quality long-term follow-up studies have not been included. Large-scale and high quality clinical studies are required for further valuation.关键词
利妥昔单抗/肺炎/Meta分析/随机对照试验Key words
Rituximab/Pneumonia/Meta-analysis/Randomized controlled trials分类
医药卫生引用本文复制引用
白浩,孙朴,陈霞..利妥昔单抗注射液相关性肺炎的Meta分析[J].中国药房,2018,29(4):547-552,6.基金项目
重庆市科委基础与前沿研究计划项目(No. cstc2013jcyjA10125) （No. cstc2013jcyjA10125）
重庆市沙坪坝区科委社会发展领域科技项目(No. 沙科委发〔2016〕41号-SF201601) （No. 沙科委发〔2016〕41号-SF201601）
