中国药房2018，Vol.29Issue(5)：670-674,5.DOI:10.6039/j.issn.1001-0408.2018.05.24
马来酸依那普利叶酸片对H型高血压并发2型糖尿病患者颈动脉粥样硬化的影响及可能机制
Effects of Enalapril Maleate Folic Acid Tablets on Carotid Atherosclerosis in H Type Hypertension Patients with Type 2 Diabetes Mellitus and Its Potential Mechanism
摘要
Abstract
OBJECTIVE: To investigate the effects of Enalapril maleate folic acid tablets on carotid atherosclerosis in H type hypertension patients with type 2 diabetes mellitus (T2DM) and its potential mechanism.METHODS: In prospective control study, 182 H type hypertension patients with T2DM were selected from Chongqing People's Hospital during Jan. 2014-Jan. 2016, and then randomly divided into observation group and control group, with 91 cases in each group. All patients received basic or hypoglycemic treatment of premixed insulin; observation group was additionally given Enalapril maleate folic acid tablets (containing enalapril maleate 10 mg, folic acid 0. 8 mg in each tablet) orally, one tablet, qd; control group was additionally given Enalapril maleate tablets (containing enalapril maleate 10 mg in each tablet) orally, one tablet, qd. Treatment course lasted for 12 months. The levels of blood pressure, plasma homocysteine (Hcy), fasting blood glucose (FBG), C-reactive protein (CRP) and carotid plaque score were detected in 2 groups before treatment, 12 months after treatment. RESULTS: Compared to before treatment, SBP and DBP of 2 groups were decreased significantly in 2 groups after 12 months of treatment (P<0. 05); there was no statistical significance between 2 groups (P>0. 05). The levels of plasma Hcy, FBG and CRP, carotid intima-media thickness and carotid plaque integral in observation group were significantly lower than control group (P<0. 05). CONCLUSIONS: Enalapril maleate folic acid tablets can relieve inflammation by reducing plasma Hcy, FBG and CRP so as to treat carotid atherosclerosis in H type hypertension patients with T2DM.关键词
H型高血压/2型糖尿病/马来酸依那普利叶酸片/动脉粥样硬化Key words
H type hypertension/Type 2 diabetes mellitus/Enalapril maleate folic acid tablets/Atherosclerosis分类
医药卫生引用本文复制引用
罗羽慧,梅霞,金平,郑向清,贺锐,柳亚敏..马来酸依那普利叶酸片对H型高血压并发2型糖尿病患者颈动脉粥样硬化的影响及可能机制[J].中国药房,2018,29(5):670-674,5.基金项目
国家十二五"重大新药创制"科技重大专项(No.2012ZX09101105) （No.2012ZX09101105）
重庆市卫生局医学科研计划项目(No.2011-2-370) （No.2011-2-370）
