中国药房2018，Vol.29Issue(12)：1612-1616,5.DOI:10.6039/j.issn.1001-0408.2018.12.07
微波消解-电感耦合等离子体质谱法测定棓丙酯氯化钠注射液中8种金属元素的含量
Content Determination of 8 Metal Elements in Propylgaclate and Sodium Chloride Injection by Microwave Digestion-inductively Coupled Plasma Mass Spectrometry
摘要
Abstract
OBJECTIVE:To establish a method for the content determination of 8 metal elements in Propylgaclate and sodium chloride injection. METHODS:Microwave digestion-inductively coupled plasma mass spectrometry(ICP-MS) was adopted. Radiofrequency power was 1 530 W;cooling temperature was 4 ℃;collision gas was He gas;carrier gas was argon;flow rate of carrier gas was 1.08 L/min;integration time was 0.3 s;plasma gas flow rate was 15 L/min;the vacuum degree of quadrupole was 3.04×10－4 Pa;sampling cone aperture was 1.0 mm;interception cone aperture was 0.4 mm;the speed of sampling was 0.3 rps;data collection was repeated for 3 times. The microwave digestion power is 1 600 W,and the heating process is heated to 160℃at room temperature for 30 min,and maintained at 5 min,and then heated to 190 ℃ at a temperature of 5 ℃/min and maintained 45 min. RESULTS:The linear range of Mg and Al were 1-250 ng/mL;the linear range of Cr,Mn,Fe,Cu,Zn,Cd were 1-100 ng/ mL(all r≥0.999 0). The limits of detection were 0.063 6-1.785 0 ng/mL. RSDs of precision,stability and reproducibility tests were all lower than 4%. The recoveries were 89.65%-105.60%(RSD were 1.57%-3.98%,n＝9). RSDs of durablity were all lower than 12%. CONCLUSIONS:The method is simple,accurate,precise,stable,reproducible and durable. It can be used for content determination of 8 metal elements in Propylgaclate and sodium chloride injection.关键词
棓丙酯氯化钠注射液/微波消解-电感耦合等离子体质谱法/金属元素Key words
Propylgaclate and sodium chloride injection/Microwave digestion-inductively coupled plasma mass spectrometry/Metal elements分类
医药卫生引用本文复制引用
钟振华,涂明珠,万星,夏红英,程奇珍..微波消解-电感耦合等离子体质谱法测定棓丙酯氯化钠注射液中8种金属元素的含量[J].中国药房,2018,29(12):1612-1616,5.基金项目
国家药品抽验项目(2015) （2015）
江西省食品药品监督管理局科研项目(No.2016YP16) （No.2016YP16）
