中国药房2018，Vol.29Issue(12)：1689-1692,4.DOI:10.6039/j.issn.1001-0408.2018.12.24
羟考酮静脉自控镇痛对腹腔镜下宫颈癌根治术后患者相关指标的影响
Effects of Oxycodone Patient-controlled Intravenous Analgesia on Related Indicators of Patients after Laparoscopic Radical Resection of Cervical Cancer
摘要
Abstract
OBJECTIVE:To investigate the effects of oxycodone patient-controlled intravenous analgesia (PCIA) on related indicators of patients after laparoscopic radical resection of cervical cancer. METHODS:A total of 120 patients underwent selective laparoscopic radical resection of cervical cancer were selected from our hospital during Feb. 2016-May 2017. They were divided into control group(60 cases)and observation group(60 cases)according to random number table. After laparoscopic radical resection of cervical cancer,control group was given Fentanyl citrate injection 20 μg/kg,added into 0.9% Sodium chloride injection to 150 mL, at 3.5 mL/h with initial dose of 4 mL,PCIA dose of 2 mL and self-control locking time of 10 min. Observation group was given Oxycodone hydrochloride injection 0.4 mg/kg,added into 0.9%Sodium chloride injection to 150 mL,at 3.5 mL/h with initial dose of 4 mL,PCIA dose of 2 mL and self-control locking time of 10 min. VAS scores 12,24,48 h after surgery,serum levels of IFN-γ, IL-10,NK cells,CD3+,CD4+and CD8+30 min before surgery and 24,48,72 h after surgery,the occurrence of ADR were observed in 2 groups. RESULTS:All patients of both groups completed the study. VAS scores of 2 groups 24,48 h after surgery were significantly lower than 12 h after surgery,with statistical significance (P＜0.05). There was no statistical significance between 2 groups(P＞0.05). Thirty min before surgery,there was no statistical significance in the levels of IFN-γ,IL-10,NK cells,CD3+, CD4+or CD8+between 2 groups(P＞0.05);24,48,72 h after surgery,the levels of IFN-γ and IL-10 in 2 groups were significantly higher than 30 min before surgery,and the observation group was lower than the control group,with statistical significance(P＜0.05);the levels of NK cells,CD3+,CD4+and CD8+in 2 groups were significantly lower than 30 min before surgery,but increased gradually as time;the indexes above of observation group was significantly higher than the control group 24,48 h after surgery,with statistical significance(P＜0.05). The incidence of ADR in observation group(8.33%)was significantly lower than control group (20.00%),with statistical significance(P＜0.05). CONCLUSIONS:Oxycodone PCIA shows good analgesic effect after laparoscopic radical resection of cervical cancer and can effectively decrease the levels of serum inflammatory factors and improve immune function with good safety.关键词
羟考酮/芬太尼/腹腔镜下宫颈癌根治术/镇痛效果/炎症因子/免疫功能/安全性Key words
Oxycodone/Fentanyl/Laparoscopic radical resection of cervical cancer/Inflammatory factors/Immune function/Safety分类
医药卫生引用本文复制引用
卢建华,吴周晏,林颖,陈霞..羟考酮静脉自控镇痛对腹腔镜下宫颈癌根治术后患者相关指标的影响[J].中国药房,2018,29(12):1689-1692,4.基金项目
广西壮族自治区卫生和计划生育委员会自筹经费科研项目(No.Z2016186) （No.Z2016186）
