中国医科大学学报2018，Vol.47Issue(2)：114-118,5.DOI:10.12007/j.issn.02584646.2018.02.005
广西人群miR-17-92基因簇启动子区rs1491033A/C和rs1813389A/G多态性研究
Study of the Polymorphisms rs1491033A/C and rs1813389A/G in the miR-17-92 Gene Cluster Promoter Region in a Guangxi Population
摘要
Abstract
Objective To investigate the distribution of the polymorphisms rs1491033A/C and rs1813389A/G in the promoter region of the miR-17-92 gene cluster in a normal population of Guangxi and compare this distribution with that in different ethnic groups. Methods We detected the genotypes of rs1491033A/C and rs1813389A/G of 275 people from Guangxi using the SNaPshot technique and DNA sequencing. We then analyzed the genotype and allele frequency distribution differences among different genders and groups. Results Three genotypes,AA,AC,and CC,were found for rs1491033A/C with frequency distributions of 21. 1％,53. 1％,and 25. 8％, respectively. There were significant differences in genotype and allele frequencies of rs1491033A/C between the Guangxi population and those of Europe and Africa,as published in the International HapMap project (P < 0. 05). Three genotypes,AA,AG,and GG were observed for rs1813389A/G with frequency distributions of 40. 0％,50. 2％,and 9. 8％,respectively. There were significant differences in the genotype and allele frequencies of rs1813389A/G between the Guangxi population and those of Europe,Beijing,Japan,and Africa (P <0. 05). However,there were no significant differences in genotype or allele frequencies of the rs1491033A/C or rs1813389A/G polymorphisms between genders in the Guangxi population (P > 0. 05). Conclusion There are different distributions of the rs1491033A/C and rs1813389A/G polymorphisms in the miR-17-92 gene cluster in different races and regions.关键词
miR-17-92基因簇/多态性/种族Key words
miR-17-92 gene cluster/gene polymorphism/ethnic分类
生物科学引用本文复制引用
王荣,覃海媚,陆玉兰,黄华佗,蓝艳,王俊利,韦叶生..广西人群miR-17-92基因簇启动子区rs1491033A/C和rs1813389A/G多态性研究[J].中国医科大学学报,2018,47(2):114-118,5.基金项目
国家自然科学基金(81560552,81260234) （81560552,81260234）
