中国医科大学学报2018，Vol.47Issue(2)：119-122,144,5.DOI:10.12007/j.issn.02584646.2018.02.006
小脑锌指结构4在子宫内膜癌组织中的表达及意义
Expression of ZIC4 in Endometrial Carcinoma and Its Significance
摘要
Abstract
Objective To investigate zinc finger of the cerebellum 4(ZIC4) expression in endometrial cancer tissue and its relationship with clinicopathological parameters. Methods Immunohistochemistry was used to detect ZIC4 expression in endometrial paraffin specimens. Results The positivity rate of ZIC4 expression in atypical hyperplasia and endometrial carcinoma was higher than that in normal endometrial tissue. ZIC4 expression was correlated with the clinical stage,differentiation,depth of uterine invasion,and lymph node metastasis of endometrial cancer. Survival analysis revealed that patients with endometrial cancer who had low ZIC4 expression levels had better prognosis. Conclusion The ZIC4 expression level in endometrial carcinoma is significantly increased;thus,ZIC4 expression level can be used to monitor the prognosis of patients with endometrial cancer.关键词
ZIC4/子宫内膜癌/临床病理参数Key words
zinc finger of the cerebellum 4/endometrial cancer/clinicopathological parameter分类
医药卫生引用本文复制引用
马剑,孔繁菲,丛蓉,马晓欣..小脑锌指结构4在子宫内膜癌组织中的表达及意义[J].中国医科大学学报,2018,47(2):119-122,144,5.基金项目
国家自然科学基金(81472438,81272874) （81472438,81272874）
沈阳市科学技术计划(F14-158-9-47) （F14-158-9-47）
盛京自由研究者基金(201601) （201601）
