中国医科大学学报2018，Vol.47Issue(3)：222-225,4.DOI:10.12007/j.issn.0258-4646.2018.03.007
小细胞肺癌中DBC1的表达及预后相关性研究
Expression of DBC1 in Small Cell Lung Cancer Tissues and Correlation with Prognosis
摘要
Abstract
Objective To investigate the expression of deleted in breast cancer 1 (DBC1) in small cell lung cancer (SCLC) and its correlation with prognosis. Methods The clinical data of 73 SCLC patients who underwent surgery in Shengjing Hospital of China Medical University between December 2009 and June 2013 were retrospectively analyzed. The expression levels of DBC1 in lung cancer tissues were detected using quantitative real-time polymerase chain reaction (RT-PCR). The correlation between the expression of DBC1 and the clinicopathological parameters of SCLC patients were analyzed. The Kaplan-Meier method was used to analyze the relationship between DBC1 expression and survival of the SCLC patients; independent factors of prognosis were analyzed using the COX proportional hazards model. Results The expression of DBC1 was significantly associated with recurrence and metastasis (P ＜ 0. 05), whereas it was not significant correlated with the patients gender, age, pathological type, stage, and smoking history. Results of the Kaplan-Meier analysis showed that survival rates were significantly decreased in patients with higher DBC1 expression levels when compared to those with lower expression levels (P ＜ 0. 01). COX proportional hazard model analysis showed that the expression of DBC1 can be used as an independent factor for the prognosis of SCLC patients. Conclusion High expression of DBC1 is correlated with recurrence and metastasis of SCLC, and associated with poorer prognosis in SCLC patients.关键词
乳腺癌缺失基因1/小细胞肺癌/复发转移/预后Key words
deleted in breast cancer-1/small cell lung cancer/recurrence and metastasis/prognosis分类
医药卫生引用本文复制引用
张苏宁,刘宗昂..小细胞肺癌中DBC1的表达及预后相关性研究[J].中国医科大学学报,2018,47(3):222-225,4.基金项目
辽宁省自然科学基金(LFWK201708) （LFWK201708）
