中国药理学通报2018，Vol.34Issue(7)：898-902,5.DOI:10.3969/j.issn.1001-1978.2018.07.004
肿瘤代谢物2-HG与胶质瘤发生发展及其检测
Oncometabolite 2-HG in glioma evolution and recent progress of detection method
摘要
Abstract
IDH mutation is prevalent in lower-grade glioma and secondary glioblastoma. Patients bearing IDH mutation are char-acterized by overproduction of 2-HG. 2-HG plays a role in regu-lation of DNA and histone hypermethylation in glioma, thus re-sulting in impaired cell differentiation and tumor formation. As a surrogate marker of mutant IDH, there is increasing interest in development of detection methods for 2-HG. LC-MS is widely used in detecting 2-HG in vitro, and reliable measurement of 2-HG by the non-invasive MRS has been tested in vivo and ex vivo previously. However, whether 2-HG could represent an inde-pendent predictor of patient survival or other clinical features for glioma still needs further study. In this review, we summarize the mechanism adopted by 2-HG in glioma initiation and pro-gression, as well as the detection method tested in clinic. We try to provide guidance to the future combination therapy using mu-tant IDH inhibitors.关键词
神经胶质瘤/IDH突变/异柠檬酸脱氢酶/2-羟基戊二酸/检测方法/肿瘤治疗Key words
glioma/IDH mutation/isocitric dehydrogenase/2-HG/detection method/cancer therapy分类
医药卫生引用本文复制引用
陈妍红,陈小平..肿瘤代谢物2-HG与胶质瘤发生发展及其检测[J].中国药理学通报,2018,34(7):898-902,5.基金项目
国家自然科学基金资助项目(No 81703622) （No 81703622）
