中国药理学通报2018，Vol.34Issue(7)：906-909,4.DOI:10.3969/j.issn.1001-1978.2018.07.006
酒精相关胃癌发生的分子机制
Molecular mechanism of alcohol-associated gastric cancer
摘要
Abstract
Gastric cancer is the second most common cancer in China. Alcohol consumption is related to gastric cancer as a sig-nificant risk factor. Some key enzymes is expected to influence the alcohol-associated metabolism. There are many molecular mechanisms of alcohol-related gastric cancer, such as generation of acetaldehyde by microbiome, inflammation, up-regulation of Pol Ⅲ genes, carcinogen-DNA adduct formation and genetic polymorphisms of alcohol metabolizing enzymes. Different types and concentrations of alcohol have different effects on the devel-opment of gastric cancer. This review presents a systematic ex-position on the molecular mechanism of alcohol-associated gastric cancer.关键词
胃肿瘤/酒精/乙醛/癌变/分子生物学/机制Key words
stomach neoplasms/ethanol/acetaldehyde/carci-nogenesis/molecular biology/mechanism分类
医药卫生引用本文复制引用
张逸寅,王华,顾康生..酒精相关胃癌发生的分子机制[J].中国药理学通报,2018,34(7):906-909,4.基金项目
安徽省对外科技合作项目(No 1604b0602027) （No 1604b0602027）
