中国药理学通报2018，Vol.34Issue(7)：940-946,7.DOI:10.3969/j.issn.1001-1978.2018.07.011
α-苯基-N-叔丁基硝酮对MPP+/MPTP诱发帕金森病模型的神经保护作用
Study on neuroprotection of α-phenyl-N-tert-butyl nitrone for anti-Parkinson's disease in vitro and in vivo
文婷 1付永莉 1罗婷 1周坤 1李鸿杰1
作者信息
- 1. 华中科技大学同济医学院附属武汉精神卫生中心药学部,湖北 武汉 430022
- 折叠
摘要
Abstract
Aim To discuss the neuroprotection of an-tioxidant α-phenyl-N-tert-butyl nitrone ( PBN) in Par-kinson's disease ( PD) model. Methods The neuro-protective effects of PBN was explored on 1-methyl-4-phenylpyridinium/1-methyl-4-phenyl-1,2,3,6-tetrahy-dropyridine ( MPP+/MPTP ) induced PD models through a chemical releasing of free radicals in neurons and in vivo. Results PBN significantly scavenged chemical derived free radicals, reduced MPP+induced SH-SY5Y injury and enhanced neurons' viability. In MPTP induced PD model, PBN significantly enhanced the number of tyrosine hydroxylase ( TH)-positive do-pamine ( DA) neurons in the substantia nigra, restored the expression of Nrf2 and HO-1, and raised striatal contents of DA and its metabolites. Conclusion PBN has a potent neuroprotective effect against MPP+/MPTP induced PD models.关键词
α-苯基-N-叔丁基硝酮/帕金森病/多巴胺能神经元/氧化应激/自由基/神经保护Key words
PBN/Parkinson's disease/dopamine neurons/oxidative stress/free radicals/neuroprotec-tion分类
医药卫生引用本文复制引用
文婷,付永莉,罗婷,周坤,李鸿杰..α-苯基-N-叔丁基硝酮对MPP+/MPTP诱发帕金森病模型的神经保护作用[J].中国药理学通报,2018,34(7):940-946,7.
