摘要
Abstract
Objective To analyze the risk factors and pathogenic bacteria in patients of antibiotic associated diarrhea (AAD) with chronic obstructive pulmonary disease (COPD) in our hospital. Method 165 cases of hospitalized patients with COPD combined with AAD in our hospital were selected from January 2013 to December 2016, the general condition, clinical manifestation and distribution and drug resistance of pathogenic bacteria were analyzed retrospectively, the relationship between the species and antibiotic dosage and duration of treatment with AAD were observed. Result 171 strains of pathogenic bacteria were isolated from 165 samples, in which 133 strains (77.78%) were Gram-negative bacteria and Escherichia coli were the most; 32 strains (18.71%) of Gram-positive bacteria and Enterococcus faecalis were the most; 6 strains (3.51%) of fungi and Candida albicans was the most. The older the patient, the more widely used antibiotics and the longer the duration of antibiotic treatment, the higher the incidence of AAD (P＜0.05). Multidrug-resistant Gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, baumanii, Pseudomonas aeruginosa had different degrees of resistance to common antibiotics. Conclusion Strictly grasp of the indications of antibiotic use, rational use of antibiotics and minimize invasive operation can effectively reduce the occurrence of diarrhea.关键词
慢性阻塞性肺疾病/机械通气/抗生素相关性腹泻/病原菌/耐药Key words
Chronic obstructive pulmonary disease/Mechanical ventilation/Antibiotic associated diarrhea/Pathogenic bacteria/Drug resistance
