中国医学前沿杂志（电子版）2018，Vol.10Issue(4)：115-118,4.DOI:10.12037/YXQY.2018.04-26
持续膀胱内压监测下家猪腹腔高压模型的构建及评价
Construction and evaluation of abdominal compartment syndrome model in swine under pressure sensor monitoring
摘要
Abstract
Objective To establish a stable IAH/ACS model of swine to observe the effects of different intra-abdominal pressure on respiratory and blood pH and electrolyte levels, so as to provide references for clinical diagnosis and treatment. Method 24 healthy adult swine were randomly divided into control group (8 cases), IAH group (8 cases) and ACS group (8 cases). Under the monitoring of intravesical pressure, IAH/ACS models were created by injecting nitrogen into abdominal cavity of swine in IAH group and ACS group. The arterial blood gas analysis, blood pH, and electrolyte levels of three groups were compared. Result There were significant differences in pH, PaO2, PaCO2and HCO3-in swine of the control group, IAH group and ACS group (P＜0.05). As the intra-abdominal pressure increased, the arterial blood pH, PaO2, and HCO3-respectively decreased, and the PaCO2increased gradually. There were significant differences in blood K+levels and Ca2+levels between three groups of swine (P＜0.05). As the intra-abdominal pressure increased, Ca2+gradually decreased and K+gradually increased. There were no significant difference in Na+and Cl-concentrations between three groups of swine (P＞0.05). Conclusion The ACS model of swine designed in this study has the characteristics of simple operation, stable intra-abdominal pressure maintenance, and good real-environmental simulation. It has a significant injury effect and can significantly affect the circulatory respiratory function, blood pH, and electrolyte levels of swine. They will be aggravated when IAH increases, and may eventually showing ACS performance.关键词
腹腔内高压/腹腔间室综合征/动物模型Key words
Intra-abdominal hypertension/Abdominal compartment syndrome/Animal model引用本文复制引用
张洪彬,鲁曦,朱育春..持续膀胱内压监测下家猪腹腔高压模型的构建及评价[J].中国医学前沿杂志（电子版）,2018,10(4):115-118,4.基金项目
四川省卫生厅科研课题(150013817) （150013817）
