中国中医药信息杂志2018，Vol.25Issue(7)：87-91,5.DOI:10.3969/j.issn.1005-5304.2018.07.021
金匮肾气丸加减干预高血压病系统评价
Systematic Review of Jinkui Shenqi Pills on Hypertension
摘要
Abstract
Objective To evaluate the efficacy and safety of Jinkui Shenqi Pills on hypertension through Meta-analysis and systematic review. Methods Articles about intervention of modified Jinkui Shenqi Pills in hypertensive clinical randomized controlled trials were retrieved from CNKI, Wanfang database, VIP, Cochrane Library, PubMed, and Embase. They were all searched from inception to June 2016. Cochrane system evaluation manual bias risk assessment method was used to evaluate the quality of the articles, and RevMan5.3 software was used for Meta-analysis. Results Nine articles involving 776 cases were included in the study. Meta-analysis showed that the total effective rate of modified Jinkui Shenqi Pills was better than that of conventional Western medicine treatment [OR=2.67, 95%CI (1.73, 4.11), P＜0.000 01], and combination therapy was superior to conventional Western medicine alone [OR=3.27, 95%CI (1.99, 5.39), P＜0.000 01]. However, the efficacy of modified Jinkui Shenqi Pills alone was equivalent to the conventional Western medicine alone [OR=1.16, 95%CI (0.43, 3.09), P=0.77). Conclusion Modified Jinkui Shenqi Pills can improve the clinical symptoms of the patients with hypertension, and combination treatment can improve the antihypertensive effect. However, the quality of the included research literature is too low, yet more large-scale, multi-center, high-quality clinical randomized controlled trials are needed to further verify.关键词
金匮肾气丸/高血压/随机对照试验/系统评价/Meta分析Key words
Jinkui Shenqi Pills/hypertension/randomized controlled trials/systematic review/Meta-analysis分类
医药卫生引用本文复制引用
崔晓荣,马学竹,李秋艳..金匮肾气丸加减干预高血压病系统评价[J].中国中医药信息杂志,2018,25(7):87-91,5.基金项目
中国中医科学院"名医名家传承"工作室建设项目(CM2014GD1022) （CM2014GD1022）
