浙江医学2018，Vol.40Issue(9)：944-948,972,6.DOI:10.12056/j.issn.1006-2785.2018.40.9.2017-2390
时间-平均血尿酸水平与新发慢性肾脏病的关系研究
Association between time-mean serum uric acid levels and chronic kidney disease
叶美玉 1胡康 1金娟 2胡培英 3何强2
作者信息
- 1. 310053 杭州, 浙江中医药大学第二临床医学院
- 2. 浙江省人民医院肾脏病科
- 3. 浙江省人民医院体检中心
- 折叠
摘要
Abstract
Objective To investigate the association between time-mean serum uric acid (SUA) levels and chronic kidney disease (CKD). Methods Clinical data of 5 701 subjects undergoing annually health check-up between January 2011 and December 2016 were retrospectively analyzed. All participants had an estimated glomerular filtration rate(eGFR) ＞60ml/min/1.73m2 at baseline. The uric acid and eGFR were assessed every year in the follow-up period. The subjects were classified into 4 groups according the sex-specific quartiles of time-mean SUA values. The risk of new development of CKD among different stratified groups was evaluated. Results During 6 years of follow-up, 249(4.4％) participants developed CKD. Multivariate analysis showed that compared to the reference, the odds ratio (OR) for the new cases of CKD increased with higher time-mean SUA levels (OR=2.709, 95％ CI:1.836-5.293, OR=3.754, 95％ CI:1.898-7.428 and OR=7.462, 95％ CI: 3.694-15.073, for the second, third and fourth quartiles respectively; all P＜0.05). Multivariate Cox proportional hazard model after adjustment for potential confounders showed that the adjusted HRs of highest quartile vs. lowest quartile for baseline and time-mean uric acid were 1.689 (95％ CI:1.058-2.696) and 6.320 (95％ C/:3.285-12.159), respectively. Conclusion The Increasing of baseline SUA and time-mean SUA value is independently associated with increased likelihood for eGFR decline and incidence CKD in the general population.关键词
血尿酸/时间-平均血尿酸/慢性肾脏病/高尿酸血症Key words
Serum uric acid/Time-mean serum uric acid/Chronic kidney disease/Hyperuricemia引用本文复制引用
叶美玉,胡康,金娟,胡培英,何强..时间-平均血尿酸水平与新发慢性肾脏病的关系研究[J].浙江医学,2018,40(9):944-948,972,6.
