浙江医学2018，Vol.40Issue(9)：952-955,4.DOI:10.12056/j.issn.1006-2785.2018.40.9.2017-1421
参麦注射液对冠心病早期胃癌患者内镜黏膜下剥离术后心功能的影响研究
Effect of Shenmai injection on cardiac function in coronary heart disease patients with early gastric cancer undergoing endoscopic submucosal dissection
陈飞 1刘国伟2
作者信息
- 1. 311800 浙江省诸暨市人民医院消化内科
- 2. 辉瑞(北京)国际医学院临床药学研究中心
- 折叠
摘要
Abstract
Objective To investigate the effect of Shenmai injection on heart function in coronary heart disease (CHD) patients with early gastric cancer undergoing endoscopic submucosal dissection (ESD). Methods Sixty CHD patients with early gastric cancer undergoing ESD were randomly divided into control group and study group with 30 cases in each group. Patients in control group received conventional care and patients in study group received additional intraveous infusion of Shenmai injection 100ml q.d. from 1d before ESD to 2 weeks after ESD. Heart function including E/A, LVEF was compared between two groups. Serum levels of troponin- I (cTn I), creatine kinase isoenzyme (CK-MB), creatine kinase (CK), reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC) were detected and compared in two groups. Results The E/A and LVEF in study group were significantly higher than those in control group at all time points (P＜0.05). Serum levels of cTnl, CK, CK-MB, ROS and MDA in study group were significantly lower, while SOD and T-AOC were significantly higher than those in control group at all time points (P＜0.05). Conclusion Shenmai injection can improve oxidative stress level and protect cardiac function in CHD patients with early gastric cancer undergoing endoscopic submucosal dissection.关键词
参麦注射液/早期胃癌/内镜黏膜下剥离术/心功能Key words
Shenmai injection/Early gastric cancer/Endoscopic submucosal dissection/Heart function引用本文复制引用
陈飞,刘国伟..参麦注射液对冠心病早期胃癌患者内镜黏膜下剥离术后心功能的影响研究[J].浙江医学,2018,40(9):952-955,4.
