中南民族大学学报（自然科学版）2018，Vol.37Issue(2)：63-66,4.
多花黄精"九蒸九制"后化学成分及生物活性研究
Chemical Constituents and Bioactivity from Polygonatum cyrtonema Hua.after " Nine-steam-nine-bask"
摘要
Abstract
The chemical constituents from the methanol extract of Polygonatum cyrtonema Hua after " nine-steam-nine-bask" were isolated and purified by a combination of various chromatographic techniques including silica gel,Sephadex LH-20,medium pressure liquid chromatography and high performance liquid chromatography.Eight compounds were obtained and elucidated from fraction 1 by modern spectrum technology as alternariol(2),cyclo-(L-Leu -L-Ile)(2),5,7-dihydroxy-6,8-dimethyl-3-(4'-hydroxybenzyl)chroman-4-one(3),5,7-dihydroxy-6-methyl-8-methoxy-3-(4'-hydroxybenzyl)chroman-4-one(4),3-(9,12-Octadecadienoyl)glycerol(5),1,4-difuranyl-2,3-dihydroxy-1,4-butanedione(6),5-hydroxymethyl-2-furancarboxadehyde(7),8-hydroxychromone(8).In the in vitro activity assays,compound 6 showed obvious anti-inflammatory activity and the inhibition rate was 44.8％,the IC50value was 35.5 μmol/L(57.9％and 26.5 μmol/L for the reference).However,compound 6 had no inhibitory effect on pancveatic lipase.关键词
多花黄精/九蒸九制/化学成分/生物活性Key words
Polygonatum cyrtonema Hua/nine-steam-nine-bask/chemical constituents/biological activity分类
化学化工引用本文复制引用
海梅荣,达布希拉图,蔡金龙,耿仕娴,王文祥..多花黄精"九蒸九制"后化学成分及生物活性研究[J].中南民族大学学报（自然科学版）,2018,37(2):63-66,4.基金项目
农业部重大专项项目(2017AB002) （2017AB002）
云南省科技厅资助项目(2016RA030) （2016RA030）
