中药材2017，Vol.40Issue(11)：2644-2648,5.DOI:10.13863/j.issn1001-4454.2017.11.033
星点设计-效应面法优化葛花醒酒颗粒的提取工艺
Optimization of Extraction for Gehua Xingjiu Keli by Central Composite Design-Response Surface Method
摘要
Abstract
To optimize the extraction preparation of Gehua Xingjiu Keli. Methods: Evaluate the effect of extracted time,frequency, solid-liquid rate,pH, temperature, ratio of material to solvent on the transfer rate of tectoridin, ginsenoside Rg1 and isochlorogenic acid A and dry extraction yield by single factor test. And then optimized the process by central composite design-response surface method. Results: The optimize preparative parameters was as follows, the ratio of material to solvent was 1∶8. 44, the pH was 6. 45, the extraction temperature was 65 ℃, and extracted three times for 2 h. The deviation of OD value from actual value and theoretical value was -3. 62％. Conclusion: The extraction preparation of Gehua Xingjiu Keli optimize by central composite design-response surface mthod is effective.关键词
葛花醒酒颗粒/星点设计-响应面法/提取工艺Key words
Gehua Xingjiu Keli/Central Composite Design-Response Surface Method/Preparation分类
医药卫生引用本文复制引用
谭珍媛,黄兴振,梁健钦,罗勤..星点设计-效应面法优化葛花醒酒颗粒的提取工艺[J].中药材,2017,40(11):2644-2648,5.基金项目
广西壮族自治区中医药管理局科技项目(GZZJ13-16) （GZZJ13-16）
