中药材2017，Vol.40Issue(11)：2667-2680,14.DOI:10.13863/j.issn1001-4454.2017.11.040
五加生化胶囊干预气虚血瘀证的GC-MS代谢组学研究
Study of Wujia-Shenghua Capsule on Qi-deficiency and Blood-stasis Syndrome Based on GC-MS Metabolomics
摘要
Abstract
To research the effect and mechanism of Wujia-Shenghua capsul on Qi-defeciency and blood-stasis rats by metabolomics method. Methods: Based on GC-MS metabolomics, the endogenous metabolite of rat plasma was measured. Results: Fourteen potential metabolic biomakers were identified qualitatively based on GC-MS metabolomics. Wujia-Shenghua capsule could callback the content of the fourteen potential biological marker. Conclusion: Wujia-Shenghua capsule can callback the content of the common fourteen potential biological marker of Qi-defeciency and blood-stasis rats. After the preliminary analysis of the biological significance,speculate the treating function of Wujia-Shenghua capsule is expressed by adjusting energy metabolism, tricarboxylic acid cycle and amino acid metabolism.关键词
五加生化胶囊/气虚血瘀证/GC-MS/代谢组学Key words
Wujia-Shenghua capsule/Qi-defeciency and blood-stasis/GC-MS/Metabolomics分类
医药卫生引用本文复制引用
于修芳,朴成玉,董蕊,张智博,徐占玲,耿放,张宁..五加生化胶囊干预气虚血瘀证的GC-MS代谢组学研究[J].中药材,2017,40(11):2667-2680,14.基金项目
黑龙江省科技攻关计划项目(GC10C208) （GC10C208）
哈尔滨市科技创新人才研究专项资金项目(2015RQQXJ043) （2015RQQXJ043）
黑龙江中医药大学科研基金(201516,210309) （201516,210309）
