中医药学报2018，Vol.46Issue(1)：40-43,4.DOI:10.19664/j.cnki.1002-2392.180010
莱菔硫烷对酒精诱发肝脏脂肪代谢异常的预防作用及机制研究
Preventive Effect of Sulforaphane on Abnormal Lipid Metabolism of Liver Induced by Alcohol and Its Possible Mechanisms
摘要
Abstract
Objective: To investigate the effects of sulforaphane (SFN) on abnormal lipid metabolism induced by alcohol and its action mechanisms. Methods: Acute liver injury model was established with different doses of SFN in male C57BL/6 mice. The prevention effect of SFN on abnormal lipid metabolism was observed and its possible mechanism was analyzed. Results; SFN significantly alleviated the damage of the liver caused by alcohol, which showed dose - dependent relationship; it decreased the levels of TG and CHOL, but not HDL; it obviously activated the expression of Nrf2, subsequently induced the activity of phase II enzyme GST and increased the content of GSH; it also down - regulated the expression of SREBP - lc. Conclusion: SFN can regulate the disorders of lipid metabolism in liver induced by alcohol. The main mechanisms may include the followings: the activation of Nrf2, which enhances the antioxidant capability;and the inhibition of SREBPlc, which improves the abnormal lipid metabolism.关键词
莱菔硫烷/急性酒精性肝损伤/脂肪代谢/抗氧化Key words
Sulforaphane/Acute alcoholic-induced liver injury/Lipid metabolism/Antioxidant分类
医药卫生引用本文复制引用
李宝龙,赵瑶洁,刘旭,李松滨,刘永武,姜波,单毓娟..莱菔硫烷对酒精诱发肝脏脂肪代谢异常的预防作用及机制研究[J].中医药学报,2018,46(1):40-43,4.基金项目
国家自然科学基金面上项目(81573135) （81573135）
黑龙江省教育厅科学技术研究项目(12541763) （12541763）
