中医药学报2018，Vol.46Issue(1)：58-61,4.DOI:10.19664/j.cnki.1002-2392.180014
基于"痛泻要方"探讨防风对tnbs诱导大鼠UC结肠TLR-4及外周血中TNF-α、IL-1β的影响
Impact of Fangfeng in Tongxie Yaofang on TLR-4, TNF-α, and IL-1 β in UC Rats Triggered by TNBS
摘要
Abstract
Objective: To observe the impact of Tongxie Yaofang(TXYF) and Fangfeng (FF) on TLR4 expression of colonic mucosa, and on serum TNF - a and IL - 1β in ulcerative colitis (UC ) rats. Methods: UC models were established by TNBS/ethanol enema. 72 Wistar rats were randomly divided into six groups, i. e. the blank control group, the model group, FF group, TXYF without FF group, TXYF group, SASP group. The blank control group and the model group were only intervened with normal saline. Levels of TLR - 4, IL - 1β, and TNF - a were tested after four weeks. Results:The levels of TLR - 4, IL - 1β, and TNF - a were increased obviously in the model group compared to those in the blank control group(P ＜0.01); after treatment, they were decreased in FF group, TXYF - FF group, TXYF group, and SASP group, in which TXYF group and SASP group had significant statistical differences (P ＜0.01, P ＜0.05 ). Conclusion: TXYF can achieve the best therapeutic effect with FF in, its mechanism may be inhibiting the release of TLR - 4, IL - 1β and TNF - a, which also showed that FF played an important role in TXYF.关键词
痛泻要方/防风/溃疡性结肠炎/TLR-4/IL-1β/TNF-αKey words
Tongxie Yaofang/Fangfeng/Ulcerative colitis/TLR-4/IL-1β/TNF-a分类
医药卫生引用本文复制引用
郭军雄,马丽,汪斌,闫立国..基于"痛泻要方"探讨防风对tnbs诱导大鼠UC结肠TLR-4及外周血中TNF-α、IL-1β的影响[J].中医药学报,2018,46(1):58-61,4.基金项目
甘肃省教育厅基金资助项目(1030 - 02) （1030 - 02）
河西学院科研创新与应用校长基金项目(XZ2014 - 32) （XZ2014 - 32）
