中医药学报2018，Vol.46Issue(1)：83-87,5.DOI:10.19664/j.cnki.1002-2392.180020
通腑理肺汤结肠透析联合肺泡灌洗对重症肺炎合并脓毒症TNF-α、IL-6的影响
Effects of Colon Dialysis with Tongfu Lifei Decoction Combined with Alveolus Lavage on TNF-α and IL-6
摘要
Abstract
To explore the effects of the colonic dialysis with Tongfu Lifei decoction combined wtih alveolus lavage by branchofiberoscope on the levels of TNF - a and IL -6 in patients with severe pneumonia with sepsis. Methods: 90 patients were randomly divided into three groups, group A (colonic dialysis with Tongfu Lifei decoction + alveolus lavage), group B (colonic dialysis with warm water + alveolus lavage), and group C (colonic dialysis with warm water), with 30 cases in each group. The levels of IL - 6 and TNF - a in the alveolus lavage were observed before treatment, one week and two weeks after the treatment in the three groups. At the same time, scores of TCM syndromes, clinical pulmonary infection scores(CPIS), mechanical ventilation use time, and ICU staying time were recorded in the three groups. SPSS 22.0 statistical software was used for statistical analysis. Results: The total effective rates were 90％, 80％, and 63.3％ respectively in group A, group B and group C, and their differences were statistically significant(P ＜0.05). There was no statistical difference in terms of the levels of IL - 6 and TNF - a among the three groups before the treatment (P ＞0.05); however, the levels of IL -6 and TNF -α in group A were significantly lower than those of group B and group C one week and two weeks after the treatment (P ＜ 0.05 ). Scores of TCM syndromes and CPIS were decreased, breathing machine use time and ICU staying time were shortened after the treatment in the three groups, of which group A was significantly lower than group B and group C two weeks after the treatment, and the differences were statistically significant(P ＜ 0.05 ). Conclusion: The therapy of colonic dialysis with Tongfu Lifei decoction combined with alveolus lavage by branchofiberoscope can reduce the levels of IL - 6 and TNF - α, decrease scores of TCM syndromes and CPIS, shorten the respirator use time and ICU stay, increase the clinical curative effect, and improve the prognosis of the disease; its mechanism may be related to improving gastrointestinal function, reducing the levels of TNF - a and IL - 6, preventing enteric infection and multiple organ dysfunction, inhibiting excessive inflammation, and reducing tissue injury and inflammation.关键词
通腑理肺汤/结肠透析/重症肺炎/脓毒症/肺泡灌洗/TNF-α/IL-6Key words
Tongfu Lifei decoction/Colonic dialysis/Severe pneumonia/Sepsis/Alveolus lavage/TNF-α/IL-6分类
医药卫生引用本文复制引用
吕波,陈立,李兰,黄瑞峰,邹素昭,柳蔓,李慧侠..通腑理肺汤结肠透析联合肺泡灌洗对重症肺炎合并脓毒症TNF-α、IL-6的影响[J].中医药学报,2018,46(1):83-87,5.基金项目
贵州省科技计划项目(黔科合中药字[2012]LKZ7057号) （黔科合中药字[2012]LKZ7057号）
贵州省中医药管理局项目(QZYY2013 -36) （QZYY2013 -36）
贵州省科技合作计划项目(黔科合中药字[2015]7291号) （黔科合中药字[2015]7291号）
