摘要
Abstract
Objective: To observe the effects of Shenmai injection combined with thrombolytic therapy for acute myocardial infarction(AMI)patients, and to discuss its impact on ventricular function, CRP, BNP and IL-6 in serum. Methods: 84 AMI patients were randomly divided into the observation group(n =42) and the control group (n =42 ). The control group was treated with conventional thrombolytic therapy; on which basis, the observation group was also given Shenmai injection. After a course of treatment, clinical efficacy was compared between the two groups. The levels of BNP, CRP and IL-6 were detected. Also, ejection fraction and diastolic diameter of left ventricle, and adverse reaction were observed to evaluate the effect of Danshen injection in the treatment of AMI. Results: The levels of BNP, CRP and IL-6 were all decreased after the treatment, and the changes of the observation group were more obvious, with statistically significant differences(P ＜0.05). The total effective rate was 95.24％ in the observation group, which was higher than 83.33％ in the control group, but the difference was not statistically significant(P ＞0.05). Ejection fraction of left ventricle were both increased in the two groups after the treatment, in which there was a significant difference(P ＜0.05); however, the difference of diastolic diameter was not statistically significant in the two groups(P ＞ 0.05 ). In terms of adverse reactions there was no obvious difference between the two groups (P ＞0.05). Conclusion: The combination of Shenmai injection with thrombolytic therapy was superior to thrombolytic therapy alone in improving the level of BNP, CRP and IL -6, reducing the incidence of adverse reaction, which is of great clinical significance.关键词
参麦注射液/溶栓治疗/急性心肌梗塞/心室功能Key words
Shenmai injection/Thrombolytic therapy/Acute myocardial infarction/Ventricular function分类
医药卫生
