按摩与康复医学2018，Vol.9Issue(11)：45-47,3.
桔梗皂苷D的大鼠血浆药代动力学研究
Pharmacokinetic research of kikyosaponin D in rat plasma
摘要
Abstract
Objective: To investigate in-body movement of kikyosaponin D in rat. Methods: animal experiment used SD rats, water extract of Platycodon grandiflorum was given orally, and blood sample was taken with 24 hours; pharmacokinetic research was carried out using kikyosaponin D as index, and HPLC method for determination, with Phenomenex C18 column and acetonitrile-0.1％ phosphoric acid as mobile phase, the injection volume was 10μl, column temperature was 30℃, detection wavelength was 203nm. Results: pharmacokinetic parameter of kikyosaponin D was Tmax=0.69±0.44,Cmax=21.819±1.16,AUC(0-τ)=44.132±0.67, MRT=2.00±0.75, CL=228±0.80. Conclusion: oral administration of kikyosaponin D had a fast metabolism, while with lower bioavailability; however, such parameters was acceptable for Platycodon grandiflorum to achieve its effect for enhancing therapeutic of other medications.关键词
桔梗皂苷D/药代动力学/生物利用度Key words
kikyosaponin D/Pharmacokinetics/Bioavailability分类
医药卫生引用本文复制引用
邓杏好,谭梅英,张维彬..桔梗皂苷D的大鼠血浆药代动力学研究[J].按摩与康复医学,2018,9(11):45-47,3.基金项目
佛山市科学技术局课题,2014AB002493 （）
