广东医学2018，Vol.39Issue(5)：696-700,5.
动脉插管灌注化疗联合125I放射性粒子植入治疗胰腺癌
Clinical study of arterial infusion chemotherapy combined with iodine-125 seed implantation in treating patients with pancreatic cancer
摘要
Abstract
Objective To investigate the effect of arterial infusion chemotherapy combined with iodine-125 (125 I) seed implantation in treating patients with pancreatic cancer. Methods Fifty patients with pancreatic cancer were divided into two groups by using random number method. Traditional venous chemotherapy was adopted in control group (n= 25), while arterial infusion chemotherapy combined with 125 I seed implantation was adopted in observation group (n = 25). After 2 courses of chemotherapy or 1 month after the seed implantation, the treatment efficacy, pain relief, quality of life and survival time were evaluated. Results After treatment, no significant difference was observed in the objective response rate (ORR) or the disease control rate (DCR) between the 2 groups (P ＞ 0. 05). Pain relief, KPS score, clinical benefit response, and quality of life in observation group were significantly better than those in control group (P ＜ 0. 05). No significant difference was observed in the median progression free survival (PFS) or the median overall survival (OS) between the 2 groups (P ＞ 0. 05). Conclusion Arterial infusion chemotherapy combined with 125 I seed implantation in treating patients with pancreatic cancer has a better clinical effect than traditional venous chemotherapy. It can effectively alleviate pain, improve quality of life, and prolong survival.关键词
胰腺癌/动脉插管灌注/化疗/125I放射性粒子Key words
pancreatic cancer/arterial intubation infusion/chemotherapy/iodine-125 seed implantation引用本文复制引用
吴轩,潘海东,张未芳,蔡豹,王东红,李文敏..动脉插管灌注化疗联合125I放射性粒子植入治疗胰腺癌[J].广东医学,2018,39(5):696-700,5.基金项目
东莞市科技局科技研究项目(编号: 201410515000563) （编号: 201410515000563）
