广西医学2018，Vol.40Issue(12)：1302-1304,3.DOI:10.11675/j.issn.0253-4304.2018.12.07
结直肠癌患者血浆p73基因甲基化异常情况及其临床意义
Methylation abnormality of plasma p73 gene and its clinical significance in colorectal cancer
摘要
Abstract
Objective To explore the methylation abnormality of plasma p73 gene and its clinical significance in patients with colorectal cancer. Methods Totally 142 patients with colorectal cancer were enrolled,including 64 with colorectal cancer(colorectal cancer group)and 78 with colorectal tumor(colorectal tumor group),and 142 healthy volunteers as healthy control group. The methylation of plasma p73 gene was detected by the methylation specific PCR,and the content of serum carcinoembryonic antigen(CEA) was determined by chemiluminescent immunoassay. The methylation of plasma p73 gene and positive rate of serum CEA were compared among the three groups,and the positive rates of plasma p73 gene methylation were compared among the patients with colorectal cancer of different clinical pathological characteristics. Results The positive rates of plasma p73 gene methylation and CEA increased in the order of the control group, the colorectal tumor group and the colorectal cancer group(P<0. 05). Among the patients with colorectal cancer,there were statistically significant differences in the positive rate of plasma p73 gene methylation between different tumor diameters,different infiltrating depths, different organ types,or different clinical stages(all P<0. 05). Conclusion The positive rate of plasma p73 gene is quite high in patients with colorectal cancer. Detection of plasma p73 gene methylation might be valuable in the early diagnosis of colorectal cancer.关键词
p73基因/甲基化/结直肠癌Key words
p73 gene/methylation/Colorectal cancer分类
医药卫生引用本文复制引用
龙海华,贾安平,尹琦,庞丽萍,梁秀兰..结直肠癌患者血浆p73基因甲基化异常情况及其临床意义[J].广西医学,2018,40(12):1302-1304,3.基金项目
广西柳州市科学研究与技术开发计划(2014J030425) （2014J030425）
