广西医学2018，Vol.40Issue(12)：1321-1323,3.DOI:10.11675/j.issn.0253-4304.2018.12.13
阻塞性睡眠呼吸暂停低通气综合征患者单核细胞/高密度脂蛋白胆固醇比值及其临床意义
Monocyte count-to-high density lipoprotein-cholesterol ratio in obstructive sleep apnea hypopnea syndrome and its clinical significance
童梓德 1赖世佳1
作者信息
- 1. 厦门大学附属成功医院耳鼻喉科,福建省厦门市 361003
- 折叠
摘要
Abstract
Objective To investigate the monocyte count-to-high density lipoprotein-cholesterol ratio(MHR) in obstructive sleep apnea hypopnea syndrome(OSAHS) and its clinical significance. Methods Totally 86 patients with OSAHS were enrolled as OSAHS group,and were divided into mild group(n=32),moderate group(n=30) and severe group(n=24) according to the apnea-hypopnea index(AHI). Another 32 healthy subjects without OSAHS confirmed by polysomnography were selected as control group. The monocyte count(MC),HDL-C and MHR were compared among all groups. And the correlations of serum MC,HDL-C and MHR with AHI and the lowest blood oxygen saturation were analyzed. Results MC and MHR were higher but HDL-C level was lower in the OSAHS group than those in the control group(P<0. 05). MC and MHR decreased in turn in the severe,moderate and mild OSAHS groups(all P>0. 05). Pearson correlation analysis revealed that MC or MHR positively correlated with AHI,but negatively correlated with the lowest blood oxygen saturation,and HDL-C positively correlated with the lowest blood oxygen saturation(all P<0. 05). Conclusion Elevated MHR is seen in the OSAHS patients and MHR increases with the increasing severity of OSAHS,indicating MHR might be a new inflammatory factor for predicting the severity of OSAHS.关键词
阻塞性睡眠呼吸暂停低通气综合征/单核细胞/高密度脂蛋白胆固醇比值Key words
Obstructive sleep apnea hypopnea syndrome/Monocyte count-to-high density lipoprotein-cholesterol ratio分类
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童梓德,赖世佳..阻塞性睡眠呼吸暂停低通气综合征患者单核细胞/高密度脂蛋白胆固醇比值及其临床意义[J].广西医学,2018,40(12):1321-1323,3.
