西北国防医学杂志2018，Vol.39Issue(4)：216-220,5.DOI:10.16021/j.cnki.1007-8622.2018.04.002
维药买朱尼对种植体周围炎中龈下微生物的影响研究
Effect of Maizhuni on subgingival microorganism in peri-implantitis
摘要
Abstract
Objective: To analyze the influnce of Maizhuni on subgingival microbes and periodontal index in the peri-implantitis, and to evaluate the effect of Maizhuni in peri-implantitis. Methods: An animal model of peri-implantitis in Beagle dogs was established successfully and were randomly divided into three groups: treatment group, control group and antibiotic group. The treatment group was treated with Maizhuni by gavage, based on the conversion of the animal's body weight to take the drug for 4 weeks. The control group was given same dose of saline by gavage. The antibiotic group was given antibiotics by gavage (amoxicillin capsules and metronidazole tablets). The Porphyromonas gingivalis, Bacterium forsythus, Treponemas denticola, Prevotella intermedia, Fusobacterium nucleatum, probing depth(PD), bleedingn on probing(BOP) and peri-implant sulcular fluid (PISF) index were obeserved in the three groups. Results: The PD, PISF, BOP index and the detection rate of the five sub-microorganisms in antibiotics group and treatment group after treatment were lower than those in inflammatory stage, but higher than those in normal level(P＜0.01), and there were significant difference compared with control group(P＜0.01). The detection rates of Pg, Bf and Pi in antibiotic group were lower than those in treatment group, there was no statistically difference in other index. Conclusion: Maizhuni is more effective in treating soft tissue inflammation, and it has antibacterial effect but relatively non-significant. Therefore, it is necessary to conduct antibacterial experiments.关键词
种植体周围炎/维药买朱尼/牙龈卟啉单胞菌/福赛拟杆菌/齿垢密螺旋体/中间普氏菌/具核梭杆菌Key words
peri-implantitis/Maizhuni/Porphyromonas gingivalis/Bacteroides forsythus/Treponema denticola/Prevotella intermedia/Fusobacterium nucleatum分类
医药卫生引用本文复制引用
王冰杰,王雪,段子文,杨超,尼加提·吐尔逊..维药买朱尼对种植体周围炎中龈下微生物的影响研究[J].西北国防医学杂志,2018,39(4):216-220,5.基金项目
新疆维吾尔自治区自然科学基金项目(2016D01C192) （2016D01C192）
