中国感染控制杂志2018，Vol.17Issue(3)：191-195,5.DOI:10.3969/j.issn.1671-9638.2018.03.002
河北省五市结核分枝杆菌耐药情况及耐多药菌株对利奈唑胺的敏感性
Drug resistance of Mycobacterium tuberculosis and susceptibility of multidrug-resistant strains to linezolid in 5cities in Hebei Province
摘要
Abstract
Objective To understand the drug resistance of Mycobacterium tuberculosis(MTB)and susceptibility of multidrug-resistant MTB(MDR-MTB)to linezolid in Hebei Province, so as to guiding clinical treatment of MDR tuberculosis.Methods The isolated strains and clinical information of patients with tuberculosis in 6 hospitals of 5 cities in Hebei Province between January and December 2016 were collected, susceptibility of MTB to antituberculous drugs isoniazid(INH), rifampicin(RFP), streptomycin(SM), ethambutol(EMB), ofloxacin(OFX), and kanamycin(KM)were detected, 100 strains of MDR-MTB were selected by stratified random sampling method, susceptibility to linezolid was detected.Results Drug resistance rate and MDR rate of the initially treated cases were 26.6％(200/753)and 13.5％(102/753)respectively, drug resistance rate and MDR rate of the retreatment cases were 59.7％(132/221)and 53.4(118/221)respectively, drug resistance rate and MDR rate of the retreatment cases were both statistically higher than initially treated cases(χ2=83.7, P＜0.01;χ2=93.5, P＜0.01).Resistance rates of MTB to first-line antituberculous drugs INH, RFP, SM, and EMB were 25.8％, 23.7％, 16.7％, and 7.1％ respectively, to second-line antituberculous drugs OFX and KM were 4.7％(37/782)and 4.0％(31/782)respectively; susceptibility of MDR-MTB to linezolid was 80.8％ (59/73).Conclusion Drug resistance rate and MDR rate of the retreated tuberculosis patients are higher than initially treated patients, linezolid has good in vitro antimicrobial activity against MDR-MTB.关键词
结核病/结核分枝杆菌/利奈唑胺/耐多药/体外敏感性Key words
tuberculosis/Mycobacterium tuberculosis/linezolid/multidrug resistance/in vitro antimicrobial susceptibility分类
医药卫生引用本文复制引用
许怡,张志,田岳飏,李雅楠,高会霞..河北省五市结核分枝杆菌耐药情况及耐多药菌株对利奈唑胺的敏感性[J].中国感染控制杂志,2018,17(3):191-195,5.基金项目
河北省医学科研重点课题项目(20150155) （20150155）
