中国现代医学杂志2018，Vol.28Issue(19)：41-44,4.DOI:10.3969/j.issn.1005-8982.2018.19.008
MicroRNA-1469低表达与食管鳞状细胞癌临床病理特征及预后的关系
Relationships of low expression of miR-1469 with progression and clinical outcomes of esophageal squamous cell carcinoma
李亚俊 1顾晓静 1杨乐 1边虹2
作者信息
- 1. 宁夏医科大学总医院消化内科,宁夏 银川 750004
- 2. 宁夏医科大学总医院胸外科,宁夏 银川 750004
- 折叠
摘要
Abstract
Objective To explore the relationships of low expression of miR-1469 with progression and unfavorable post-surgical clinical outcomes in patients with esophageal squamous cell carcinoma. Methods The expression of miR-1469 was detected by qRT-PCR in the patients who successfully underwent esophagectomy for esophageal squamous cell carcinoma. Then χ2 test, Kaplan-Meier method, and Log-rank test were performed. Results There were statistical differences in cancer invasion depth, lymph node metastasis and pathologic stage between the miR-1469 low-expression and high-expression groups (P < 0.05). The patients with miR-1469 low expression had significantly lower disease-free survival rate (17.9% vs. 42.8%, P = 0.004) and post-operative 5-year overall survival rate (29.31% vs. 47.1%, P = 0.027). miR-1469 low expression significantly predicted unfavorable 5-year disease-free survival rate among the patients with N1-3(7.3% vs 31.5%, P = 0.043). Conclusions The expression of miR-1469 could predict disease progression and post-surgical clinical outcomes for patients with esophageal squamous cell carcinoma.关键词
microRNA-1469/食管鳞状细胞癌/预后Key words
miR-1469/esophageal squamous cell carcinoma/prognosis分类
医药卫生引用本文复制引用
李亚俊,顾晓静,杨乐,边虹..MicroRNA-1469低表达与食管鳞状细胞癌临床病理特征及预后的关系[J].中国现代医学杂志,2018,28(19):41-44,4.
