摘要
Abstract
Objective To detect the level of homocysteine in peripheral blood of chronic eczema patients with depression, and to investigate the correlation between the level of homocysteine and the disease. Methods Totally 108 outpatients with chronic eczema, who were treated in Department of Dermatology in the Second Affiliated Hospital, University of South China from June 2012 to June 2017, were retrospectively collected. According to the score of PHO-9 evaluation scale for depression state, they were divided into a control group (chronic eczema patients without depression) and an observation group (chronic eczema patients with depression). General clinical information of both groups was assessed. The levels of serum homocysteine (Hcy) and vitamin B12(Vit B12) were compared, as well as the eczema area and severity index (EASI) score and Visual AnalogueScale (VAS) score. The correlations of Hcy and Vit B12 values with the clinical features of chronic eczema patients complicated with depression were analyzed by Spearman method, and the correlations of PHQ-9 score with Hcy, Vit B12, EASI score and VAS score in the observation group were also analyzed. Results There was no significant difference in sex, age or course of disease between the two groups (P > 0.05). The peripheral blood Hcy level of the observation group was significantly higher than that of the control group, while the level of Vit B12 was significantly lower than that of the control group (P < 0.05). However, there was no significant difference in EASI score or VAS score between the two groups (P >0.05). Through the Spearman correlation analysis of 61 patients in the observation group, Hcy level was positively correlated with EASI score and VAS score, while Vit B12 level was negatively correlated with EASI score and VAS score (P < 0.05). Moreover, Hcy was negatively correlated with Vit B12 level (r = -0.503, P = 0.000). Depression scores were positively correlated with Hcy, EASI score and VAS score, but negatively correlated with Vit B12 level (P < 0.05). Conclusions Depression and chronic eczema interact with each other, and Hcy may be involved in the middle process.关键词
慢性湿疹/同型半胱氨酸/维生素B12/PHQ-9抑郁量表/EASI评分Key words
chronic eczema/homocysteine/vitamin B12/PHO-9 evaluation scale for depression state/EASI score分类
医药卫生
