中医药信息2018，Vol.35Issue(2)：53-56,4.DOI:10.19656/j.cnki.1002-2406.180052
双黄连口服液与颗粒剂微生物限度检查方法的研究
Microbial Limit Test of Oral Liquid and Granules of Shuanghuanglian
摘要
Abstract
Objective: To study the microbial limit test for oral liquid and granules of Shuanghuanglian. Methods: Microbial limit test for oral liquid and granules of Shuanghuanglian was testified by the conventional plate method, culture medium diluted method, and membrane filtration method; the recovery rates of test strains, such as staphylococcus aureus, were determined. Results: Both the oral liquid and granules of Shuanghuanglian had antibacterial activity, the recovery rates were lowered by the conventional plate method and culture medium diluted method, which could not actually reflect the contamination of the solution. The recovery rate by the membrane filtration method was significantly higher than that by culture medium diluted method, which was in accordance with the requirements. Conclusion: Membrane filtration method should be adopted in the microbial limit test for oral liquid and granules of Shuanghuanglian.关键词
双黄连口服液/双黄连颗粒剂/微生物限度检查/薄膜过滤法Key words
Shuanghuanglian oral liquid/Shuanghuanglian granules/Microbial limit test/Membrane filtration method分类
医药卫生引用本文复制引用
张乔,张琦,李静,姜德友,孟云阁..双黄连口服液与颗粒剂微生物限度检查方法的研究[J].中医药信息,2018,35(2):53-56,4.基金项目
国家自然科学基金项目(No.81073077) （No.81073077）
黑龙江省博士后科研基金资助项目(No.LBH-Z12250) （No.LBH-Z12250）
