中医药信息2018，Vol.35Issue(2)：57-61,5.DOI:10.19656/j.cnki.1002-2406.180054
星点设计-效应面法优化马钱子碱-士的宁(B-S)双载药固体脂质纳米粒的制备工艺研究
Optimal Processing of Biphasic Drug-Loading Liposome of Brucine-Strychnine with the Methodolgoy of Central Composite Design-Response Surface
摘要
Abstract
Objective: To optimize the processing of biphasic drug - loading liposome of Brucine - Strychnine(B - S) by adopting the methodolgoy of central composite design - response surface. Methods: Liposomes were prepared with emulsion solvent evaporation method, and the medicinal content was determined by HPLC. The total encapsulation efficiency and total drug loading were used as indicators. Results: The ratio of glyceryl monostearate to soybean lecithin was 2:3, the dosage of glyceryl monostearate was 60 mg, B: S was 2.62, and the dosage of F - 68 was 0.31％. Under these optimized conditions, the average particle size of liposome was105 nm, the average total encapsulation efficiency was (48.57 ±1.21)％, and the average total drug loading was (1.02 ± 0.32) ％. Conclusion: The process is simple, stable and feasible, which is suitable for preparing liposome of B - S.关键词
马钱子碱-士的宁/双载药固体脂质纳米粒/星点设计-效应面法Key words
Brucine-Strychnine/Biphasic drug-loading liposome/Methodology of central composite design-response surface分类
医药卫生引用本文复制引用
史磊,曹思思,吕邵娃,孙爽,赵程程,李永吉..星点设计-效应面法优化马钱子碱-士的宁(B-S)双载药固体脂质纳米粒的制备工艺研究[J].中医药信息,2018,35(2):57-61,5.基金项目
国家自然科学基金面上项目(No.81274091) （No.81274091）
