中国耳鼻咽喉头颈外科2018，Vol.25Issue(1)：35-37,3.DOI:10.16066/j.1672-7002.2018.01.008
白细胞介素10基因多态性与北京地区哮喘病患者的相关性研究
Association of interleukin-10 gene polymorphism with bronchial asthma in Chinese subjects in Beijing area
摘要
Abstract
OBJECTIVE The objective of this study was to investigate the association between interleukin 10 (IL-10) gene polymorphism and asthma. METHODS We tried to enroll data from 205 asthma patients and 210 controls to investigate the association between IL-10 polymorphisms and asthma in the Han Chinese population. The three common single nucleotide polymorphisms (SNPs), including rs1800896, rs1800871, rs1800872 on the promoter area of IL-10 were genotyped using the sequenom mass array technology platform. RESULTS Our results showed that rs1800872 were significantly associated with asthma. In asthma groups, we found that there was significant high concentration of total serum IgE in genotype AA comparing with genotype CC. CONCLUSION In conclusion, our data showed that rs1800872 was significantly associated with asthma.关键词
哮喘/白细胞介素10/多态性/单核苷酸Key words
Asthma/Interleukin-10/Polymorphism/ Single Nucleotide引用本文复制引用
张旭,王玉红,张媛,张罗..白细胞介素10基因多态性与北京地区哮喘病患者的相关性研究[J].中国耳鼻咽喉头颈外科,2018,25(1):35-37,3.基金项目
北京市自然科学基金 (7164247)、首都卫生发展科研专项基金 (2016-4-1092)和首都医科大学附属北京同仁医院科研基金 (2015-YJJ-ZZL-010)联合资助 （7164247）
