国际病理科学与临床杂志2018，Vol.38Issue(3)：465-471,7.DOI:10.3978/j.issn.2095-6959.2018.03.001
蒲公英萜醇对肺癌细胞的增殖及糖酵解的影响
Effect of taraxerol on proliferation and glycolysis of lung cancer cells
刘冬 1赵鹏 1王磊 1兰飞 1魏晓燕 1张贺龙1
作者信息
- 1. 空军军医大学唐都医院肿瘤科,西安 710038
- 折叠
摘要
Abstract
Objective: To study the effect of taraxerol on glycolysis of lung cancer cells. Methods: We detected the concentration of cell glucose consumption, lactic acid and cellular ATP content and NAD+/NADH by lung cancer cell lines H1299 and A549. At the same time, platelet-derived growth factor BB (PDGF-BB) was given to increase the Akt pathway to promote glycolysis reaction, and to investigate the effect of dandelion terpene on the glycolysis of lung cancer cells. Results: Taraxerol significantly reduced glucose consumption, lactate and ATP concentration, and increased NAD+/NADH concentration. While simulating H1299 and A549 cells with PDGF, glucose consumption, lactic acid concentration, cellular ATP concentration and hexokinase activity increased significantly, and NAD+/NADH concentration reduced. After taraxerol was added, glycolysis induced by PDGF-BB was reduced in H1299 and A549 cells, hexokinase activity and Akt phosphorylation were inhibited. Conclusion: Taraxerol can inhibit the level of glycolysis of lung cancer cells and inhibit hexokinase activity, which is related to the regulation of Akt pathway.关键词
肺癌/糖酵解/蒲公英萜醇Key words
lung cancer/glycolysis/taraxerol引用本文复制引用
刘冬,赵鹏,王磊,兰飞,魏晓燕,张贺龙..蒲公英萜醇对肺癌细胞的增殖及糖酵解的影响[J].国际病理科学与临床杂志,2018,38(3):465-471,7.
