国际病理科学与临床杂志2018，Vol.38Issue(3)：490-497,8.DOI:10.3978/j.issn.2095-6959.2018.03.005
IL-4和IL-13在甲状腺乳头状癌中的表达及其与临床病理特征和预后的关系
Expression of IL-4 and IL-13 in thyroid papillary carcinoma and their relationship with clinicopathological parameters and prognosis
摘要
Abstract
Objective: To investigate the expression of IL-4 and IL-13 in papillary thyroid carcinoma (PTC) and its relationship with clinicopathological features and postoperative recurrence (including metastasis). Methods: A total of 185 cases of pathologically confirmed papillary thyroid carcinoma and adjacent tissues were collected. Another 20 cases of normal thyroid tissue as a control group. Immunohistochemistry was used to detect the expression of IL-4 and IL-13 in the tissues. Results: The positive rate of IL-4 protein in cancer tissues was 95.68％, which was significantly higher than that in adjacent tissues 37.84％ and normal tissues 5.00％ (P＜0.05). The positive rate of IL-13 protein in cancer tissues was 90.81％, which was significantly higher than that in adjacent tissues 41.08％ and normal tissues 0.00％ (P＜0.05). The expression of IL-4 and IL-13 had significant relationship with clinical features such as tumor size, depth of invasion, differentiation and TNM staging (P＜0.05). The recurrence rate of high IL-4 expression group was significantly higher than that of low IL-4 expression group (χ2=5.491, P=0.019). The recurrence rate of IL-13 high expression group was significantly higher than that of IL-13 low expression group, the difference was statistically significant (χ2=4.345, P=0.037). COX regression analysis showed that high expression of IL-4 and high expression of IL-13 were independent risk factors for postoperative recurrence in patients with PCT (P＜0.05). Conclusion: IL-4 and IL-13 in PTC tumor tissue are upregulated, and are related to tumor size, depth of invasion, differentiation and TNM staging, and the high expression of IL-4 and IL-13 in tumor tissue is an independent risk factor for postoperative recurrence (including metastasis).关键词
甲状腺乳头状癌/白细胞介素-4/白细胞介素-13/临床病理特征/预后Key words
thyroid papillary carcinoma/interleukin-4/interleukin-13/clinicopathological features/prognosis引用本文复制引用
刘瑞,罗前程,朱鸿玲,尤文,沈佩玲,王星,李湘麒,顾明君..IL-4和IL-13在甲状腺乳头状癌中的表达及其与临床病理特征和预后的关系[J].国际病理科学与临床杂志,2018,38(3):490-497,8.基金项目
上海市卫生和计划生育委员会科研课题(201440050).This work was supported by Shanghai Health and Family Planning Committee Research Project, China (201440050). （201440050）
