常俊晓 1邢群智 1李毓 1韩学昌 1周民涛 1董旭 1吴悠1
作者信息
- 1. 河南科技大学临床医学院,河南科技大学第一附属医院麻醉科,河南 洛阳 471003
- 折叠
摘要
Abstract
Objective: To evaluate the influence of mechanical ventilation during perioperative period on normal pulmonary arterial blood oxygen pressure and inflammatory mediators by inhalation of different oxygen concentrations. Methods: A total of 120 patients, who underwent elective gastrointestinal tumor radical resections, were randomly assigned to four groups, including Group A with an inhalation of 35％ FiO2, Group B with an inhalation of 50％ FiO2, Group C with an inhalation of 75％ FiO2, and Group D with an inhalation of 100％ FiO2 (30 patients in each group). Blood samples were obtained from each patient before induction of anesthesia (T0), 20 min after tracheal intubation (T1), 60 min after tracheal intubation (T2), at the end of the operation (T3) and 10 min after extubation (T4) to measure serum levels of SOD, TNF-α, IL-6 and IL-10. Moreover, blood gas analysis was preformed to measure PaO2 at the same time. Results: At PaO2 level, PaO2 levels of Group C and D were significantly higher than Group A at time points of T1-3 (P＜0.01), while PaO2 level of Group B was significantly higher than that of Group A at time points of T2-3 (P＜0.01). PaO2 levels of Group B, C and D were significantly lower than that of group A at time point of T4 (P＜0.01). Moreover, at TNF-α, IL-6, IL-10 and SOD level, the serum levels of TNF-α, IL-6 and IL-10 in Group B were significantly higher than Group A, while the SOD level of Group B was significantly lower than Group A at time point of T4 (P＜0.05). The serum levels of TNF-α, IL-6 as well as IL-10 in Group C were significantly higher than Group A, while the SOD level of Group C was significantly lower than Group A at time points of T2-3 (P＜0.01). The serum levels of TNF-α, IL-6 and IL-10 of Group D were significantly higher than Group A, while the SOD level of Group D was significantly lower than that of Group A at time point of T2-4 (P＜0.05). Conclusion: The fraction of inspired oxygen at 35％ had less effect on normal pulmonary of patients with gastrointestinal tumor by arterial blood oxygen pressure and inflammatory mediators, which may be the suitable in mechanical ventilation.关键词
吸入氧浓度/机械通气/炎症介质/全身麻醉Key words
fraction of inspired oxygen/mechanical ventilation/inflammatory mediators/general anesthesia
